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2-Bromo-2-Methylpropionic Acid

Qiji Chemical

2-Bromo-2-Methylpropionic Acid
Specifications

HS Code

204107

Chemical Formula C4H7BrO2
Molar Mass 167.001 g/mol
Appearance Colorless to light yellow liquid
Boiling Point 198 - 200 °C
Melting Point 14 - 17 °C
Density 1.548 g/cm³
Solubility In Water Slightly soluble
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
Acidity Pka ~3.17
Flash Point 90 °C
Packing & Storage
Packing 500g of 2 - Bromo - 2 - Methylpropionic Acid in a sealed, chemical - resistant bottle.
Storage 2 - Bromo - 2 - Methylpropionic Acid should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container to prevent leakage and exposure to air and moisture, which could potentially lead to decomposition or unwanted reactions. Label the storage clearly for easy identification and safety.
Shipping 2 - Bromo - 2 - Methylpropionic Acid should be shipped in well - sealed, corrosion - resistant containers. It must comply with hazardous chemical shipping regulations, ensuring proper labeling and secure packaging to prevent leakage during transit.
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2-Bromo-2-Methylpropionic Acid 2-Bromo-2-Methylpropionic Acid
General Information
Historical Development
2 - Bromo - 2 - Methylpropionic Acid is an organic compound, and its historical development is quite explainable. In the past, chemical research was at the beginning, and many scholars devoted themselves to the exploration of organic synthesis. At that time, the understanding of the properties and reactions of various compounds was still shallow.
With the passage of time, chemical technology has become more and more refined. Some intelligent people noticed the relevant reaction paths, and after repeated experiments and research, they were able to prepare 2 - Bromo - 2 - Methylpropionic Acid. Early preparation may have been difficult, with low yield and poor purity.
However, scholars made unremitting efforts to optimize the reaction conditions and explore better raw materials and catalysts. After long-term accumulation, this compound can now be synthesized with high efficiency and high purity, and it has gradually developed important uses in the fields of organic synthesis, medicinal chemistry, etc., adding a strong touch to the development of chemistry.
Product Overview
Product Overview of 2-Bromo-2-methylpropionic acid
2-bromo-2-methylpropionic acid is also an organic compound. Its molecular structure is unique, containing bromine atoms and methyl groups, giving this compound unique properties.
Looking at its properties, it is often colorless to slightly yellow liquid and has a certain pungent odor. In the chemical industry, it has a wide range of uses. In organic synthesis, it is often used as a key intermediate and can participate in many reactions to produce a variety of organic products.
In terms of reactivity, due to the activity of bromine atoms, this compound can easily react with a variety of reagents such as substitution and addition, which provides convenience for the synthesis of complex organic molecules. Its preparation follows a specific chemical process and is controlled by fine operations and conditions.
2-bromo-2-methylpropionic acid has a significant role in chemical synthesis and has broad prospects. It is an important object for chemical researchers to study.
Physical & Chemical Properties
2 - Bromo - 2 - Methylpropionic Acid is an organic compound. Its physical properties are colorless to light yellow liquid at room temperature, with a pungent odor, boiling point about 198 ° C, melting point about 24 ° C, density 1.45g/cm ³, soluble in ethanol, ether and other organic solvents.
From the perspective of chemical properties, because of its carboxyl group, it is acidic and can neutralize with bases to form corresponding carboxylic salts and water. And its α-carbon is connected with a bromine atom, which is highly active and prone to nucleophilic substitution reactions, such as reacting with alcohols under alkaline conditions to form ester compounds. In addition, this compound can participate in many organic synthesis reactions and has a wide range of uses in the field of organic chemistry.
Technical Specifications & Labeling
There are chemical products today, called 2 - Bromo - 2 - Methylpropionic Acid. Its process specifications and identification (product parameters) are the key.
To make this product, the raw materials must be carefully selected and the proportions must be precisely prepared. When reacting, temperature, pressure and other conditions must be strictly controlled. If the temperature is too high, it may cause an overreaction and the product is impure; improper pressure will also affect the reaction process.
In terms of labeling, the product parameters should be clear and clear. It contains geometric ingredients and some purity, all of which should be marked in detail. On the packaging, warning labels are indispensable to inform everyone of the characteristics and risks of this product. Only in this way can we ensure that the product meets the process specifications, the identification is accurate, and the chemical process is smooth.
Preparation Method
Now to prepare 2 - Bromo - 2 - Methylpropionic Acid, the method is as follows:
Raw material and production process: Take isobutanol as the initial raw material, and react with hydrogen bromide to obtain 2 - bromo - 2 - methylpropane. Complex with potassium dichromate sulfuric acid solution oxidation, then obtain the target product 2 - Bromo - 2 - Methylpropionic Acid.
Reaction steps: First, the isobutanol and hydrogen bromide are reacted at appropriate temperature and pressure. This step requires temperature control to promote the reaction to generate 2 - bromo - 2 - methylpropane. Then, the obtained 2-bromo-2-methylpropane is mixed with the sulfuric acid solution of potassium dichromate, and the temperature is slowly increased to make the oxidation reaction occur smoothly.
Catalytic mechanism: When hydrogen bromide reacts with isobutanol, the proton of hydrohalic acid first binds to the alcohol hydroxyl group to form a hydrated ion that is easy to leave, and the bromide ion attacks nucleophilic attack to promote its substitution reaction. During the oxidation step, potassium dichromate forms a strong oxidizing chromate ion under acidic conditions, attacking the carbon-carbon bond of 2-bromo-2-methylpropane to achieve oxidative conversion, and finally obtains 2-Bromo-2-Methylpropionic Acid.
Chemical Reactions & Modifications
Taste the wonders of chemical industry, there are many changes, related to the transformation and modification of 2 - Bromo - 2 - Methylpropionic Acid, and it is worth studying in depth.
The reaction of this compound is often involved in the reaction mechanism of halogenated hydrocarbons. Its bromine atom is active and can interact with many nucleophiles. In the alkali environment, it may initiate elimination reactions to form alkene products, which is a common reaction path.
However, if you want to modify it, you need to find another way. Specific functional groups can be introduced to change its physicochemical properties. For example, after esterification, it interacts with alcohols to form corresponding esters, or its solubility and stability can be improved. Or by reduction reaction, the carboxyl group is converted and given a different activity.
All these are to explore the way of 2 - Bromo - 2 - Methylpropionic Acid and modification, hoping to be able to develop its unique effect in various fields of chemical industry, and contribute to the academic and industrial circles.
Synonyms & Product Names
2-Bromo-2-methylpropionic acid, its synonym and trade name, is very important in the field of my chemical research. This compound, also known as α-bromoisobutyric acid, is one of the synonyms. As for the trade name, different trade names may have different names. However, in many chemical markets, it is often referred to by specific codes or abbreviations for the convenience of trade. Our chemical researchers, to explore its properties and synthesis methods, in the field of organic synthesis, this compound has a wide range of uses. It can be a raw material for many reactions, and its unique structure makes the reaction have different characteristics. We also need to examine their synonyms and trade names in detail to clarify that the circulation of the market and the same substance referred to under different terms are indispensable for research and application.
Safety & Operational Standards
2 - Bromo - 2 - Safety and Operation Specifications of Methylpropionic Acid
Husband 2 - Bromo - 2 - Methylpropionic Acid is also a chemical object. Its characteristics are special, and it is useful in both the field and the field of work. However, if you want to make good use of it, you must first clarify its safety and operation.
#First, the need for storage
This product is suitable for use in a place where it is dry, dry and well-connected. Avoid open flames and high temperature to prevent it from burning. It may be flammable, and it will cause serious damage in case of fire. And it needs to be stored in equal parts of oxidation and oxidation, and it must not be mixed, so as not to cause biochemical reactions and cause serious trouble.
#Second, during operation,
during operation, the animals must wear appropriate anti-dumping equipment. If it prevents eye damage, it can protect the eyes from its harm; gas mask, which can prevent its poison from entering the body; anti-gloves, to prevent the skin from connecting. The operation is carried out in the pass, so that the smoke can be quickly drained away, so as to avoid gathering and killing people.
When using this object, it is appropriate to be careful. When measuring, according to the method of fine measuring tools, it should not be done quickly. If it is accidentally dropped, do not panic. Quickly cut the fire source first, and use suitable materials, such as sand, etc., cover the adsorption, properly collect and treat, and do not let it pollute the environment.
#3. Urgent strategy
To connect the skin, quickly wash it with a large amount of water, and wash it with soap. If you don't feel it, seek treatment immediately. If it enters the eyes, immediately wash it with physiological water or water, and it will be done as soon as possible. If you inhale it accidentally, quickly move to the new air. If you are breathing sleepy, apply oxygen and send it to the hospital urgently.
Therefore, when using it in the operation of 2-Bromo-2-Methylpropionic Acid, you must be safe and observe the operation. Only then can you avoid the benefits and make good use of this thing.
Application Area
2 - Bromo - 2 - Methylpropionic Acid is an important raw material for organic synthesis. In the field of medicine, it can be used as a key intermediate to prepare a variety of specific drugs. Through specific chemical reactions, its structure can be ingeniously modified to synthesize compounds that have curative effects on specific diseases.
In the field of materials science, this compound can participate in polymerization reactions to obtain polymer materials with special properties. Its introduction can change the physical and chemical properties of materials, such as enhancing the stability and corrosion resistance of materials.
2 - Bromo - 2 - Methylpropionic Acid also plays an important role in the development of pesticides. By rationally designing the reaction path, it can be converted into pesticide ingredients with high insecticidal and herbicidal activities, providing a strong guarantee for agricultural production.
It can be seen that 2 - Bromo - 2 - Methylpropionic Acid is of great value in many application fields and is of great significance to promote the development of related industries.
Research & Development
Today, there is 2 - Bromo - 2 - Methylpropionic Acid, which is of great significance in the research and development of our chemical research field. We have dedicated ourselves to exploring its properties and synthesis methods. After repeated experiments, we have initially obtained the synthesis path. With specific raw materials and precise steps, this compound can be prepared. However, the efficiency and purity of the synthesis still have room for improvement.
We are also concerned about its application potential in various fields, such as in organic synthesis reactions, or can be used as a key intermediate to lay the foundation for the preparation of other important compounds. Looking forward to the future, we will continue to refine the synthesis process to improve the yield and quality. At the same time, in-depth exploration of its application in new fields is expected to expand its use, contribute to the development of chemistry, and promote the research and development of this compound.
Toxicity Research
Yu is dedicated to the toxicity research of chemical products, and recently focused on 2 - Bromo - 2 - Methylpropionic Acid. Viewing its structure, the position of bromine atom and methyl group, or the unique chemical properties of it, is also related to toxicity.
Experiments have shown that in a specific reaction environment, it can release active groups and interact with biological macromolecules such as proteins and nucleic acids. In cell experiments, an appropriate amount of this substance can cause cell morphological changes and metabolic disorders.
Also consider its fate in the environment, in water, soil, or through chemical and biological transformation. Its degradation products also need to be studied in detail toxicity. Although the current research is still shallow, the road to toxicity research is long, and it is necessary to study it carefully in order to clarify its impact on organisms and the environment, and to provide evidence for protection and application.
Future Prospects
Husband 2 - Bromo - 2 - Methylpropionic Acid, it is also a thing of transformation. We look forward to the future, and there will be new expansions in the general field.
In the field of engineering, it may be the cornerstone of making new technologies, and it may be unique. Research assistants develop new technologies to solve the problem of diseases. In the field of engineering, it may be able to be exquisitely synthesized, improve the quality of general materials, and make the product more canon.
And if the science is not completed, there may be a combination of new technologies in the future, so that its properties will be developed and its uses will be expanded. I am a researcher of chemistry and diligent exploration, hoping to introduce this compound, and it will be widely used and benefit the world.
Frequently Asked Questions
What are the main uses of 2-Bromo-2-Methylpropionic Acid?
2-Bromo-2-methylpropionic acid, this is an organic compound. It has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
First, it can be used to prepare various ester compounds. Under suitable catalyst and reaction conditions, the corresponding esters can be prepared by esterification reaction with alcohols. These esters have important uses in flavors, coatings, solvents and other industries. For example, esters formed by reacting with certain specific alcohols can impart a unique aroma to fragrances, or can be used as solvents in coatings to improve coating properties.
Second, it also plays an important role in drug synthesis. Due to its unique chemical structure, it can participate in the construction of many drug molecules. Through specific reaction steps, its structure can be introduced into drug molecules to achieve regulation of drug activity, solubility, stability and other properties. In the process of many new drug development, 2-bromo-2-methylpropionic acid is often involved as a starting material or key intermediate.
Third, in the field of polymer material synthesis, it can be used as a polymerization monomer or initiator to participate in the reaction. With the help of suitable polymerization methods and co-polymerization with other monomers, polymer materials with special properties can be prepared. These materials show unique application value in plastics, rubber, fibers and other fields, such as improving material mechanical properties and chemical corrosion resistance. In conclusion, 2-bromo-2-methylpropionic acid is an indispensable substance in many fields such as organic synthesis, drug research and development, and polymer material preparation due to its structural characteristics, which is of great significance to promoting the development of related industries.
What are the physical properties of 2-Bromo-2-Methylpropionic Acid?
2-Bromo-2-methylpropionic acid, its physical properties are quite characteristic. This substance is mostly solid at room temperature, just like a simple jade lying quietly. Looking at its color, it is often as white as snow, like the snow that falls at the beginning of winter, pure and free of variegated colors.
Its melting point is in a specific range, about [X] ° C, like an invisible limit. When the temperature rises to this point, it will gradually melt from solid to liquid like ice and snow meeting warmth, opening a journey of different forms.
In addition to its solubility, it does not completely blend in water, just like oil and water are difficult to mix, and only a small part can dissolve with water. However, in the world of organic solvents, it is like a wanderer returning home, and can be easily integrated with organic solvents such as ethanol and ether, and they are inseparable from each other.
Its density is also considerable, slightly heavier than water, like a stable person, it will slowly sink in water, showing its own unique weight.
In addition, 2-bromo-2-methylpropionic acid has a certain smell, which is not fragrant, but also unique, with a little chemical-specific smell, which seems to pervade the surrounding air.
This physical property makes 2-bromo-2-methylpropionic acid have unique uses and performances in many fields, and plays an indispensable role in the stage of chemistry.
What are the synthetic methods of 2-Bromo-2-Methylpropionic Acid?
The synthesis of 2-bromo-2-methylpropionic acid has been investigated by many parties throughout the ages. The following are several common methods.
First, isobutylene is used as the starting material. The addition reaction of isobutylene and hydrogen bromide under appropriate catalyst and reaction conditions can obtain 2-bromo-2-methylpropane. This step requires attention to the reaction temperature, pressure and catalyst selection. Too high or too low temperature and inappropriate pressure may affect the reaction rate and product selectivity. Subsequently, 2-bromo-2-methylpropane is carbonylated with carbon monoxide and water in the presence of a catalyst to obtain 2-bromo-2-methylpropionic acid. This carbonylation reaction is critical to the activity and stability of the catalyst, which has a great impact on the smooth progress of the reaction and the yield of the product.
Second, 2-methylpropionic acid is used as a raw material. First, 2-methylpropionic acid and bromine are initiated with a suitable initiator under appropriate reaction conditions to carry out α-bromide reaction. In this process, factors such as the type and amount of initiator, reaction temperature and time have a significant impact on the process of α-bromide reaction and the purity of the product. If the amount of initiator is improper or the reaction time is not well controlled, it is easy to produce polybrominated by-products, which affect the purity and yield of the target product.
Third, tert-butanol is used as the starting material. Tert-butanol is first substituted with hydrobromic acid to generate 2-bromo-2-methylpropane, and the subsequent steps are similar to that of carbonylation of isobutylene to obtain 2-bromo-2-methylpropionic acid. However, the substitution reaction of tert-butanol with hydrobromic acid cannot be ignored, such as the ratio of reactants, reaction temperature and reaction time, which are all related to the formation and quality of the product.
The above methods have their own advantages and disadvantages. In the actual synthesis, the appropriate synthesis method should be carefully selected according to the availability of raw materials, the feasibility of reaction conditions, and the purity requirements of the product.
2-Bromo-2-Methylpropionic Acid to pay attention to when storing and transporting
2-Bromo-2-methylpropionic acid is an organic compound. When storing and transporting it, you need to pay attention to the following matters:
First, it is related to storage. This compound should be stored in a cool, dry and well-ventilated place. Because it is more sensitive to heat, high temperature can easily decompose or cause other chemical reactions, so it should be kept away from fire and heat sources. In addition, it must be avoided from moisture. Water or moisture may cause hydrolysis of it, resulting in damage to its quality. It needs to be placed in a sealed container to prevent contact with air. Oxygen, moisture and other components in the air may react with the compound, which may affect its purity and stability. Moreover, to be stored separately from oxidizing agents and alkalis, 2-bromo-2-methylpropionic acid has a certain acidity and will neutralize with alkalis, and oxidizing agents may also react with it in redox, causing danger.
Second, it involves transportation. During transportation, make sure that the container is tightly sealed to prevent leakage. Packaging materials must have good corrosion resistance to resist the erosion of 2-bromo-2-methylpropionic acid. According to relevant regulations, it should be properly marked to clarify its chemical properties and dangerous characteristics so that transporters and regulatory authorities can know. When transporting, choose appropriate means of transportation to prevent violent vibration and collision, so as not to cause damage to the package. At the same time, the transportation environment should maintain suitable temperature and humidity to avoid extreme conditions. Transport personnel also need to undergo professional training, familiar with the characteristics of the compound and emergency treatment methods, in case of leakage and other emergencies, they can respond quickly and properly.
In short, whether it is storing or transporting 2-bromo-2-methylpropionic acid, it is necessary to operate with caution and strictly follow relevant norms and standards to ensure the safety of personnel and the quality of the compound is not damaged.
What is the market price range for 2-Bromo-2-Methylpropionic Acid?
The price of 2-bromo-2-methylpropionic acid in the market is difficult to determine. Its price range often changes for various reasons.
First, the method of production has a great impact. If it is obtained by a simple and low-cost method, its price may be easy. However, if the process is complicated, rare materials are required, or a lot of energy is expended, the price will rise.
Furthermore, the source of materials is related to the price state. If the raw materials used are easy to obtain and the quantity is sufficient and the price is stable, the price of the product will also be stable. If raw materials are scarce, or their prices fluctuate due to weather, geography, and business conditions, the price of 2-bromo-2-methylpropionic acid also drifts with the tide.
The supply and demand of the city is also the main reason. If the city seeks prosperity for it, but the supply is limited, the price will rise. On the contrary, if the supply exceeds the demand, the merchant will sell the goods, or reduce the price.
The quality is different, and the price is also different. High-quality products are often higher than ordinary products due to strict prosecution and high purity.
According to past market conditions, the price of 2-bromo-2-methylpropionic acid varies from tens to hundreds of yuan per kilogram or from tens to hundreds of yuan. In the case of large wholesale quantities, the price may be slightly lower; when retailing, the price may be slightly higher. However, this is only an approximate number, and the exact price depends on the current market conditions, the quantity and quality of the transaction, and the negotiation between the buyer and the seller. Therefore, for real-time price determination, you should consult chemical material suppliers, traders, or carefully examine the market information of chemical products.