Bromoacetyl Bromide

Qiji Chemical

Specifications

HS Code	134157
Chemical Formula	C2H2Br2O
Molar Mass	201.845 g/mol
Appearance	Colorless to pale-yellow liquid
Odor	Pungent, irritating odor
Density	2.43 g/cm³
Boiling Point	149 - 150 °C
Melting Point	-16 °C
Solubility In Water	Reacts with water
Solubility In Organic Solvents	Soluble in many organic solvents like ether, chloroform
Flash Point	66.7 °C
Hazard Class	Corrosive, toxic
Main Use	In organic synthesis for introducing bromoacetyl groups

Packing & Storage

Packing	100 mL of Bromoacetyl Bromide in a sealed, glass bottle for secure packaging.
Storage	Bromoacetyl bromide should be stored in a cool, dry, well - ventilated area, away from heat, flames, and sources of ignition. It must be kept in a tightly - sealed container to prevent leakage, as it is highly reactive and corrosive. Store it separately from incompatible substances like oxidizing agents, bases, and reducing agents to avoid dangerous reactions.
Shipping	Bromoacetyl bromide is a hazardous chemical. It must be shipped in specialized, well - sealed containers, following strict regulations. Shipment requires proper labeling indicating its dangerous nature, with cold - chain if necessary to maintain stability.

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General Information

Historical Development

Bromoacetyl bromide is also an organic reagent. Its origin is that the early chemists studied the method of organic synthesis and sought the technology of halogenated acylation, so there is this agent. The preparation was difficult at the beginning, and the yield was quite low.
And as time goes by, science and technology advance, and the preparation method is getting better. Chemists analyze its reaction mechanism and improve the process, so that the output of bromoacetyl bromide is more abundant and the purity is also increased.
In the field of organic synthesis, bromoacetyl bromide has a wide range of uses. It can be used as an acylating agent, introducing acetyl bromide, and forming various organic compounds. It has its functions in the preparation of medicines, pesticides, and dyes. Although it was difficult to prepare in the past, the wise men did not give up their research, which led to today's development and made great contributions to the progress of chemistry.

Product Overview

Bromoacetyl bromide is also an organic reagent. Its shape is a colorless to light yellow smoky liquid with a pungent and foul odor. It is active in nature and decomposes strongly in contact with water, releasing hydrogen bromide.
This agent is widely used in the field of organic synthesis. It can be used as an acylating agent to introduce acetyl bromide into organic molecules to make esters and amides. It is also a brominating agent. In a specific reaction, the substrate is brominated.
The method of preparation is often obtained by the combination of glacial acetic acid with phosphorus tribromide or bromine and red phosphorus. However, caution should be taken when preparing and using it. Because of its strong corrosive and irritating nature, it hurts the skin, eyes and breathing. And flammable, in case of open flames, hot topics can explode. Therefore, it must be in a well-ventilated place, operate according to regulations, and take protective measures to ensure safety.

Physical & Chemical Properties

Bromoacetyl bromide is also a chemical substance. It is active, a colorless fuming liquid, and has a strong irritating odor. It dissolves in contact with water, produces hydrogen bromide and acetic acid.
It melts at about minus ten and two degrees Celsius, and boils at one hundred and forty-eight degrees. About 2.6 grams per cubic centimeter.
Bromoacetyl bromide is organically synthesized and is an important reagent. With its bromine and acetyl groups, it can react with various substances. If it encounters with alcohol, it forms an ester; if it encounters with amines, it will produce amides.
However, it is also dangerous. It is very harmful to the eyes, skin, and exhalation. It must be used with caution to prevent leakage and touch, and to ensure the safety of the environment and people.
This is the chemical property of bromoacetyl bromide. Use it to be clear about its nature and apply appropriate policies to avoid it as much as possible.

Technical Specifications & Labeling

Bromoacetyl Bromide is an important reagent in organic synthesis. Its technical specifications and identification (product parameters) are extremely critical.
Looking at its technical specifications, the purity must reach a very high level, and the impurity content must be strictly controlled. The color should be pure without obvious variegation. Its boiling point, melting point and other physical parameters also need to be accurately determined to ensure stable quality.
As for the label, the product label should clearly indicate the name "Bromoacetyl Bromide", and attach a hazard warning mark, because it is corrosive and toxic. Clear storage conditions should also be marked. It should be stored in a cool, dry and well-ventilated place, away from fire sources and oxidants. In this way, the safety and quality of the product during use, transportation and storage can be ensured.

Preparation Method

The method of making bromoacetyl bromide is related to the raw materials and production process, reaction steps and catalytic mechanism. First, an appropriate amount of acetic acid is taken, bromine is added to it, and phosphorus or its compounds are used as catalysts. At a suitable temperature, acetic acid and bromine gradually react, which is a key step.
At the beginning of the reaction, the active hydrogen of the carboxyl group in the acetic acid is gradually replaced by bromine atoms due to the action of the catalyst. First, the intermediate is formed, and then further reaction is carried out to obtain bromoacetyl bromide. The whole process needs to be controlled by temperature and speed to prevent side reactions.
After the reaction is completed, it is purified by distillation, extraction, etc. to remove impurities and obtain pure bromoacetyl bromide. The production process needs to be precisely controlled, and the proportion of raw materials, reaction time, and temperature all affect the purity and yield of the product. This is the main method for producing bromoacetyl bromide.

Chemical Reactions & Modifications

The beauty of chemistry is related to the change of substances. In today's discussion of Bromoacetyl Bromide, its chemical reaction and modification can be investigated.
Bromoacetyl Bromide is active in nature and is often a key reagent in the field of organic synthesis. Its reaction mechanism, due to the activity of bromine atoms, can interact with many functional groups. In case of hydroxyl groups, a substitution reaction can occur to form ester derivatives; in case of amino groups, amides are formed.
However, this reaction can also be optimized. First, the control of reaction conditions. Precise temperature and moderate solvent are often required to make the reaction efficient and less side reactions. Second, the purity of the product. The removal of impurities after the reaction is related to the quality of the product. The purity of the product can be improved by distillation and chromatography.
Chemical research, constant refinement. In the reaction and modification of Bromoacetyl Bromide, continuous exploration can make it more widely used and more efficient.

Synonyms & Product Names

Bromoacetyl bromide is also a reagent of organic chemistry. Its name may have another name, and similar substances also exist. Although ancient chemistry is not as prosperous as it is today, the properties and uses of substances are gradually becoming clear. Bromoacetyl bromide, with its lively nature, has many applications in the synthesis industry. In the past, scholars have also recorded many records in exploring its properties and studying its uses.
Bromoacetyl bromide, or bromoacetyl bromide, although the name is different, it is the same. In the field of chemical industry, it is an important raw material for the production of various organic compounds. Looking at ancient chemical writings, although there is no detail today, there are traces of its characteristics. Its activity is strong, and it can react with many substances, which is the key to the synthesis of new substances. Past scholars, with wisdom and diligence, explored it, making the use of bromoacetyl bromide more and more widespread in the world.

Safety & Operational Standards

"Safety and Operation Specifications of Bromoacetyl Bromide"
Fubromoacetyl bromide is a genus of chemical drugs. It is strong in nature and should be used with caution. It must follow the safety and operation regulations to ensure safety.
Bromoacetyl bromide is highly corrosive and touches the body and skin, causing burns, broken skin and rotten flesh, and the pain is unbearable. Therefore, when handling this substance, you must first prepare protective gear and thick gloves to prevent the skin from touching it; the goggles are clear, which can prevent it from splashing into the eyes and avoid damage to the eyes. Wearing protective clothing, protecting the whole body, and being airtight is perfect.
When used in a place, it should be well ventilated so that poisonous gases do not gather. Set up a ventilating device to quickly expel turbid gas to prevent the volatile gas of bromoacetyl bromide from spreading in the room and causing harm to people. And when operating the countertop, it must be clean and flat, without the fetters of sundries, so as not to spill.
When weighing bromoacetyl bromide, the method should be stable and the equipment should be accurate. Use a special device to measure what you need. Do not take more or use less. Pour into other agents, it should be slowly and evenly, and it should be accompanied by stirring to prevent them from suddenly gathering and causing disaster. When reacting, it is crucial to control temperature and time. Observe the appearance of its reaction, stay on the side, and if there is any abnormality, take countermeasures quickly.
After use, the residue should not be disposed of lightly. According to its nature, it should be classified and placed, and should not be mixed with other things. The utensils used should be cleaned immediately, and the residual bromoacetyl bromide should be removed to prevent residual corrosion.
In short, the safety and operation of bromoacetyl bromide are related to the safety of the person and the success or failure of the experiment. Operators must be cautious and follow the rules before they can use it and avoid its harm.

Application Area

Bromoacetyl Bromide is an exquisite product of chemistry with a wide range of application fields. In the field of organic synthesis, this is a key reagent. It can be used to prepare a variety of bromine-containing compounds, with its unique chemical properties, participate in various complex reaction pathways, and construct exquisite molecular structures.
In the field of drug development, Bromoacetyl Bromide also plays an important role. It can be used as an intermediate to help synthesize drug molecules with specific pharmacological activities, providing a key starting material for drug creation to overcome difficult diseases.
In the field of materials science, its application should not be underestimated. It can be used to modify the surface of materials to give them unique properties, such as improving the hydrophobicity of materials, enhancing the stability of materials, etc., thereby expanding the application range of materials and enabling them to demonstrate excellent performance in more fields.

Research & Development

In recent years, I have focused on the research of Bromoacetyl Bromide. It is lively and has a wide range of uses in the field of organic synthesis.
When it was first researched, many problems arose. To understand its reaction mechanism, it is necessary to repeatedly test, observe its changes, and remember its data. Every fallacy, re-examine the steps and scrutinize the details.
However, the effort pays off, and gradually gains. After improving the reaction conditions and optimizing the process, the purity and yield of the product have been improved. This progress is not achieved overnight, but the result of day and night research and repeated failures.
Looking to the future, I hope to expand this research result and apply it to more fields. Or combine with other compounds to develop new materials and contribute to the development of the chemical industry. Continuous refinement of technology has improved the production and application of Bromoacetyl Bromide, contributing to the progress of the industry.

Toxicity Research

Taste and smell chemical substances, its nature is unpredictable, related to people's livelihood, and also involves safety. In today's view, the toxicity of Bromoacetyl Bromide is very important.
Bromoacetyl Bromide is highly irritating and toxic. If the skin is touched by fire, it will be red, swollen and painful, or even ruptured; if it enters the eyes, it will be difficult to open the eyes, or cause damage to the eyes. If you inhale its breath by mistake, the airway will burn, cough and asthma, and lung disease will occur for a long time. If you eat it by mistake, you will have colic in the stomach, vomiting and diarrhea, and damage to the viscera.
The reason for its toxicity lies in its high chemical activity, which is easy to react with biomolecules in the body, disrupt the metabolism of cells, and damage the structure of cells. Therefore, the study of the toxicity of this substance requires caution and comprehensive protection, so as to ensure the well-being of the researcher, and also to clarify its risks and avoid its harm when the world uses this substance.

Future Prospects

Bromoacetyl bromide is also a genus of chemical materials. Looking at its materials today, it has great potential for various chemical applications. Although it is currently known that it only involves a limited field, it can be seen in the future.
In the process of organic synthesis, bromoacetyl bromide can be a key agent to promote various reactions and expand the possibility of material creation. And in the context of pharmaceutical research and development, it may emerge, help new agents, and save patients.
Furthermore, the progress of materials science is also expected to rely on its help. It can change the properties of materials and add new capabilities. It can develop its growth in electronics and architecture.
Although there may be thorns ahead, we chemical researchers should be enterprising, explore its subtleties, and tap its potential. In time, bromoacetyl bromide will be able to shine in the future technology and industry, be used by the world, and benefit all.

Frequently Asked Questions

What are the main uses of Bromoacetyl Bromide?

Bromoacetyl and bromide are both widely used. Bromoacetyl is often a key reagent in the field of organic synthesis. It can be used to introduce acetyl groups, and because of the activity of bromine atoms, it can participate in various nucleophilic substitution reactions to prepare various compounds containing special functional groups. For example, in the pharmaceutical industry, bromoacetyl is often used to prepare drug intermediates with specific biological activities, which help to construct complex drug molecular structures and pave the way for the development and production of new drugs.
And bromide is also indispensable in many fields. In the past of photography, silver bromide was the core component of photosensitive materials. Under light, silver bromide undergoes photochemical reactions to generate latent images, which are developed and fixed into visible images, making great contributions to recording life and history. In medicine, some bromide can be used as a sedative to regulate the excitability of the nervous system, relieve anxiety, insomnia and other symptoms, and bring peace to patients. In industrial production, bromide can be used as a flame retardant, added to polymer materials, which can release halogen atoms in case of fire and capture free radicals in combustion reactions, thereby inhibiting combustion spread, improving the fire resistance of materials, and ensuring the safety of production and life.

What are the physical properties of Bromoacetyl Bromide?

Bromoacetyl bromide is an organic compound with unique physical properties. It is a colorless to light yellow fuming liquid with a pungent odor and an uncomfortable smell.
Bromoacetyl bromide has a high boiling point, about 149-154 ° C, which makes it change from liquid to gaseous under certain temperature conditions. Its melting point is relatively low, around -96 ° C, which means that it is liquid at room temperature and easy to solidify at low temperatures.
The density of this substance is greater than that of water, about 2.075 g/mL. When mixed with water, it will sink to the bottom of the water. Bromoacetyl bromide reacts in water and is unstable, so it is difficult to dissolve in water. However, in some organic solvents, such as ether, chloroform, etc., it has good solubility and can be uniformly mixed with these organic solvents.
In addition, bromoacetyl bromide is highly volatile and volatile in the air, forming smoke. This characteristic requires special attention when using and storing, because its volatilization may not only cause material loss, but also the volatile gas is irritating and harmful to the human respiratory tract.

What are the chemical properties of Bromoacetyl Bromide?

Bromoacetyl and bromide are both bromine-containing chemicals. They have unique and interesting chemical properties and play key roles in many chemical reactions and industrial processes.
Bromoacetyl often appears as an active acylating agent. In its molecular structure, bromine atoms are connected to acetyl groups, giving this compound a high degree of reactivity. Due to the electron-absorbing effect of bromine atoms, carbonyl carbons are more positively charged and vulnerable to attack by nucleophiles. For example, in organic synthesis, nucleophiles such as alcohols or amines can easily react with bromoacetyl to form corresponding esters or amides. This property makes bromoacetyl an important raw material for the preparation of special structural organic compounds. In the field of medicinal chemistry, it is used to construct molecular structures with specific physiological activities.
As for bromide, it covers a wide range of bromine-containing compounds, such as metal bromide and organic bromide. Metal bromide, such as sodium bromide and potassium bromide, can ionize bromine ions in aqueous solution. These bromine ions are used as reactants or catalysts in some inorganic reactions and participate in many oxidation-reduction reactions and precipitation reactions. For example, silver bromide decomposes under light, which makes it widely used in photosensitive materials of traditional photography techniques.
Among organic bromides, some of them have unique reactivity due to the presence of carbon-bromine bonds. Some organic bromides can be used as alkylation reagents to introduce alkyl groups into target molecules under suitable reaction conditions. However, some organic bromides have poor chemical stability. When exposed to heat, light or specific reagents, the carbon-bromine bond is prone to fracture, causing various chemical reactions, or generating free radicals, which in turn participate in free radical chain reactions.
Overall, bromoacetyl is unique in the specific field of organic synthesis due to its acylation activity; bromide is unique in the specific field of organic synthesis due to its wide variety, covering inorganic and organic categories, and it can develop its capabilities in different chemical reaction types. Both occupy an indispensable position in the vast world of chemical industry and scientific research.

What is the preparation method of Bromoacetyl Bromide?

To prepare bromoacetyl bromide, the method is as follows:
Take an appropriate amount of glacial acetic acid and place it in a clean reaction vessel. Gradually add bromine, and in this process, pay attention to control the reaction temperature, do not make it too high, so as to ensure the smooth progress of the reaction. The two interact and gradually change.
Then, add an appropriate amount of red phosphorus or sulfur as a catalyst. This catalyst can accelerate the reaction and make the reaction process smoother. At this time, in the reaction system, various substances are intertwined with each other, and the reaction continues to advance.
During the reaction, closely monitor the reaction phenomenon and temperature changes. When the reaction reaches the expected level and the amount of product generated meets the needs, then go through a series of separation and purification steps.
Separation method, according to the nature of the product and impurities, the appropriate means can be selected. If the boiling point is different, the bromoacetyl bromide is separated from the reaction mixture by distillation. During purification, the residual impurities are removed to make the obtained bromoacetyl bromide more pure, and the desired product can be obtained. In this way, it is also a method of producing bromoacetyl bromide.

What are the precautions when using Bromoacetyl Bromide

When using bromoacetyl and bromide, there are many key things to pay attention to.
First, safety protection must be comprehensive. Bromoacetyl and bromide are both toxic and corrosive. Before starting to operate, be sure to wear complete protective equipment, such as protective gloves, goggles and protective clothing. If the skin comes into contact accidentally, rinse with a lot of water immediately, and then seek medical treatment according to the specific situation. If it is not careful, rinse with a lot of water immediately and seek medical attention quickly.
Second, the operating environment is very important. Operate in a well-ventilated place, preferably in a fume hood, to prevent the accumulation of harmful gases and endanger health. At the same time, keep away from fire and heat sources, because bromoacetyl and bromide may be dangerous when exposed to heat or open flames.
Third, storage should also be cautious. Bromoacetyl and bromide should be stored in a cool, dry and ventilated place away from direct sunlight. At the same time, it should be stored separately from oxidants, alkalis and other substances to prevent reactions.
Fourth, the access operation should be fine. When taking bromoacetyl and bromide, be sure to use special tools and operate strictly according to the specified dosage. The weighing process should be accurate to avoid unnecessary waste or danger.
Fifth, follow-up treatment should not be ignored. After the experiment is completed, the remaining bromoacetyl and bromide should be properly disposed of and should not be discarded at will. For waste containing bromoacetyl and bromide, it is necessary to collect and treat them in accordance with relevant regulations to prevent pollution to the environment. Throughout the process of using bromoacetyl and bromide, a high degree of vigilance must be maintained and operating procedures must be strictly followed to ensure the safe and smooth operation of the experiment.