Qiji Chemical
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Ethyl 2-Bromopropionate

Qiji Chemical

Ethyl 2-Bromopropionate
Specifications

HS Code

176420

Chemical Formula C5H9BrO2
Molar Mass 167.027 g/mol
Appearance Colorless to light yellow liquid
Odor Pungent odor
Density 1.359 g/cm³ at 20 °C
Boiling Point 148 - 150 °C
Melting Point -35 °C
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in many organic solvents like ethanol, ether
Flash Point 46 °C
Refractive Index 1.435 - 1.437 at 20 °C
Packing & Storage
Packing 100 - gram bottle of Ethyl 2 - Bromopropionate, tightly sealed for chemical safety.
Storage Ethyl 2 - Bromopropionate should be stored in a cool, well - ventilated area away from heat, sparks, and open flames due to its flammability. Keep it in a tightly sealed container to prevent vapor release. Store it separately from oxidizing agents and bases as it can react with them. Ensure storage areas are dry to avoid hydrolysis reactions.
Shipping Ethyl 2 - Bromopropionate is shipped in tightly - sealed, corrosion - resistant containers. It's transported in accordance with hazardous chemical regulations, ensuring proper handling to prevent spills and potential risks during transit.
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Ethyl 2-Bromopropionate Ethyl 2-Bromopropionate
General Information
Historical Development
Ethyl 2-Bromopropionate is a compound commonly used in organic synthesis. Looking at its historical development, early chemists began to pay attention to such halogenated propionates when exploring the reaction of organic halides. At that time, organic chemistry was still in its infancy, and many reaction mechanisms were unknown, so researchers worked tirelessly. As time went by, the synthesis method gradually improved. In the past, complex and inefficient methods were used, and after repeated experiments and improvements, new synthesis paths were developed to improve yield and purity. This compound is widely used in medicine, fragrances and other fields, promoting the development of related industries. Chemists continue to explore its new characteristics and applications. In the long river of organic synthesis, Ethyl 2-Bromopropionate is flourishing, and there may be more breakthroughs in the future.
Product Overview
Ethyl 2 - Bromopropionate is an organic compound with a colorless to pale yellow liquid and a special odor. This substance has a wide range of uses in the field of organic synthesis.
In the process of chemical synthesis, propionic acid is often prepared by a specific chemical reaction with bromine and ethanol as raw materials. In the structure of this compound, the ethyl group is connected to the propionic acid base, and the bromine atom is in the 2-position. This unique structure gives it a specific chemical activity.
Because of its bromine atom, it can participate in nucleophilic substitution reactions and is often used as a key reactant in the preparation of various organic intermediates. In the field of medicinal chemistry, or an important building block for the synthesis of specific drug molecules; in the field of materials science, or can be used to prepare polymers with special properties. Its chemical properties are active, and it is necessary to operate cautiously according to the reaction conditions when participating in the reaction to ensure the smooth progress of the reaction in order to obtain the desired product.
Physical & Chemical Properties
Ethyl 2 - Bromopropionate is also an organic compound. Its physical and chemical properties can be studied. Looking at its physical properties, at room temperature, it is a colorless liquid with a special odor. Its boiling point is between 142 and 145 degrees Celsius, which is caused by the force between molecules. The density is about 1.31 g/cm ³, which is heavier than water, so it sinks when placed in water.
In terms of its chemical properties, the molecule contains bromine atoms and ester groups. Bromine atoms are active and prone to substitution reactions. In case of nucleophiles, bromine can be replaced. If it reacts with sodium alcohol, it can form ether compounds. Ester groups are also active and can be hydrolyzed. Under the catalysis of acids or bases, propionic acid and ethanol are hydrolyzed. When catalyzed by alkali, hydrolysis is faster. The wonders of its properties all stem from the characteristics of molecular structure. It is widely used in organic synthesis and can be used as a raw material for many reactions, helping chemists to produce a variety of products.
Technical Specifications & Labeling
Nowadays, there is a method for making Ethyl 2-Bromopropionate, and its technical regulations and labeling (commodity parameters) are of paramount importance. The preparation of this product is based on propionic acid and ethanol, and an appropriate catalyst is used to control the temperature to a suitable degree to carry out the esterification reaction.
In the technical regulations, the material ratio must be accurate. The ratio of propionic acid to ethanol should also be appropriate according to a specific number. Too much or too little can affect the yield and quality. The reaction temperature should be stable and should not fluctuate greatly, otherwise the product will be impure.
In terms of labeling, its color should be colorless to yellowish transparent. To measure its purity, it must reach a certain standard, and the impurity content should be extremely low. Measure its density, boiling point and other parameters, and must also match the established value to be a qualified product. In this way, strict compliance with technical regulations and clear identification can produce high-quality Ethyl 2-Bromopropionate.
Preparation Method
Ethyl 2 - Bromopropionate is an organic compound. The preparation method, raw materials and production process are very important. The raw materials are often based on propionic acid and ethanol, supplemented by a brominating agent.
First, propionic acid and ethanol are used as the starting point, and the esterification reaction is carried out under specific catalytic conditions. This step requires temperature control, time control, and catalyst selection to promote the high efficiency of esterification. The reaction is roughly as follows: Propionic acid and ethanol under the action of the catalyst gradually generate ethyl propionate.
Then a brominating agent is introduced to bromide ethyl propionate. This reaction requires careful selection of reaction conditions, such as the amount of brominating agent, reaction temperature and duration. Ethyl 2 - Bromopropionate was obtained by bromination of ethyl propionate under suitable conditions.
The whole preparation process, the reaction steps are interlocking, and the precise control of each step is extremely important. And a suitable catalytic mechanism should be constructed to increase the reaction efficiency and product purity, so that the high quality Ethyl 2 - Bromopropionate can be obtained.
Chemical Reactions & Modifications
Ethyl 2 - Bromopropionate is also an organic compound. In the research of chemistry, its chemical reaction and chemical properties are quite valuable.
To observe its chemical reaction, when it encounters nucleophilic reagents, halogen atoms can be easily replaced. If it encounters alkoxides, it can form a genus of ethers. This should follow the path of nucleophilic substitution, and use the activity of halogen atoms to attract the nucleophilic part of the reagent to attack, resulting in bond breaking and formation.
As for the chemical properties, due to the ester group and halogen atoms, it is unique. The ester group can be hydrolyzed, and in the environment of acid and base, it can be dissolved into acids and alcohols; the halogen atom makes it electrophilic and can respond to polynucleophiles.
If you want to improve its chemical reaction and modulation, you can change it, such as temperature control and pressure, and choose suitable solvents and catalysts. The structure of allergens can also guide the change of reaction and chemistry. Through various methods, Ethyl 2-Bromopropionate can be used more widely in the chemical industry and research.
Synonyms & Product Names
Ethyl 2 - Bromopropionate is also a chemical product. Its trade name is the same, and it is worth exploring.
This product name has ethyl 2-bromopropionate. In the commercial context, or due to differences in use and product quality, there are different trade names. However, it basically refers to this chemical product.
Those who are researched need to clarify the same name and trade name in order to communicate and commercialize. Knowing the same name, such as ethyl 2-bromopropionate, can enable the user to check the information in the text and not lose the relationship due to the name. The trade name of the product can be traded in the process.
Ethyl 2 - Bromopropionate, the same trade name, is an indispensable part of the research and development of chemistry, and needs to be determined by the developer.
Safety & Operational Standards
"Ethyl 2 - Bromopropionate Safety and Operation Code"
Ethyl 2 - Bromopropionate is a common chemical in chemical research. Safety is of paramount importance in its experimental operation and storage, and specific operating standards must be strictly followed.
For storage, keep in a cool, dry and well-ventilated place. Do not mix with oxidizing agents, strong alkalis and other substances to prevent violent chemical reactions and cause danger. Ethyl 2 - Bromopropionate is active in nature and prone to changes when encountering such substances.
When operating, the experimenter must wear appropriate protective clothing, such as laboratory clothes, protective gloves, etc., to protect the skin. Eye protection is also indispensable, and goggles should be worn to prevent it from splashing into the eyes and damaging the eyesight. The operating environment must be well ventilated. If conditions permit, it is best to operate in a fume hood to avoid the accumulation of harmful gases and endanger the human body.
When taking Ethyl 2 - Bromopropionate, the action should be slow and steady to avoid it spilling. If it is accidentally spilled, take corresponding cleaning measures immediately. First use materials with good adsorption properties, such as vermiculite, sand, etc., absorb it, then collect it properly, and dispose of it according to the prescribed waste treatment process. Do not discard it at will to avoid polluting the environment.
During the reaction process, it is necessary to precisely control the reaction conditions, such as temperature, pressure, and the proportion of reactants. Due to its high reactivity, a little carelessness may cause the reaction to go out of control. In the event of an accident, such as fire, leakage, etc., the personnel present should remain calm and act quickly according to the established emergency plan to minimize the harm.
In general, during the use of Ethyl 2 - Bromopropionate, safety and standard operations are carried out throughout. The success or failure of the experiment and the safety of the human body and the environment should not be taken lightly.
Application Area
Ethyl 2 - Bromopropionate is an organic compound. Its application field is quite wide. In the process of pharmaceutical synthesis, it can be used as a key intermediate. For example, when synthesizing specific anti-infective drugs, with its unique chemical structure, it can participate in many reaction steps to help build complex drug molecular structures.
In the fragrance industry, it also has extraordinary performance. Due to its chemical properties, it can be cleverly prepared to give spices a different smell and characteristics, adding a unique charm. In the field of materials science, Ethyl 2 - Bromopropionate participates in reactions and can improve certain properties of materials, such as enhancing the stability of materials or giving them special functions. Its application in various fields is due to its unique chemical composition and active reactivity, contributing to the development of many industries.
Research & Development
There is a chemical thing today, called Ethyl 2 - Bromopropionate, which our generation has studied for a long time. This material has unique characteristics and has great potential in various fields of chemical industry.
We have studied its reaction mechanism in detail and tried it in various ways, hoping to improve its preparation techniques. When experimenting, we carefully observe its changes and record every bit, in order to be accurate. After repeated attempts, we have gradually gained some results in terms of conditions control and raw material ratio.
Looking at its application prospects, it can be used as an intermediary in organic synthesis to derive many products. However, in order to expand its use, it is still difficult to overcome. Such as improving yield, reducing costs, and optimizing processes to make the process simpler and more efficient.
Our researchers, with unremitting efforts and continuous research, hope to make great achievements in the research and development of Ethyl 2 - Bromopropionate, and contribute to the development of chemistry, so as to achieve its greater function in various industries.
Toxicity Research
There is a chemical substance today, named Ethyl 2 - Bromopropionate. As a chemical researcher, the toxicity of this substance is the most important.
Ethyl 2 - Bromopropionate has the properties of halogenated esters, or because of halogen atoms and ester groups, it shows specific toxicity. It enters the organism, or interferes with the order of cell metabolism. Halogen atoms are highly active, or interact with biological macromolecules such as proteins and nucleic acids, resulting in structural and functional changes. Hydrolysis of ester groups, or production of acidic substances, messes up the balance of acid and base in the body.
According to experimental observations, it may have signs of organ damage to the tested organisms. In animal experiments, the liver and kidney function index is abnormal, which may indicate that it can damage the liver and kidney. However, the study of toxicity still needs extensive and in-depth research to explore the details of its toxicology, to clarify the relationship between dose and effect, in order to guide protection and application, to prevent it from harming life, and to benefit its use.
Future Prospects
I have studied Ethyl 2 - Bromopropionate, and I know that it has great potential in the field of chemical industry. Future development may open up new avenues in pharmaceutical synthesis. Its unique structure can be used as a key cornerstone for the creation of special drugs. Using it as a guide to synthesize new agents may solve the dilemma of many diseases.
Furthermore, the field of materials also has prospects. With its characteristics, it may be able to develop materials with strange functions for use in high-tech fields, such as electronics and aerospace.
And its method of chemical reaction is also expected to revolutionize. Optimize the process, increase productivity, reduce energy consumption, and make chemical production more efficient and clean.
This is the future of Ethyl 2 - Bromopropionate, and we should study it diligently to unlock its endless capabilities.
Frequently Asked Questions
What are the chemical properties of Ethyl 2-Bromopropionate?
Ethyl 2-bromopropionate (ethyl 2-bromopropionate) is also an organic compound. Its chemical properties are unique and can be explored quite a bit.
In this compound, the bromine atom is active and often leads to the reaction of nucleophilic substitution. Cover bromine is a good leaving group, and it is easy to be replaced by nucleophilic reagents when it encounters nucleophilic reagents. If it reacts with alcohols in an alkaline environment, it can initiate nucleophilic substitution to produce corresponding esters. This is a common method for making esters in organic synthesis. It also reacts with amines to form amides, which play a significant role in the preparation of nitrogen-containing organics.
Furthermore, its ester groups are also active. Under the catalysis of acid or base, it can be hydrolyzed into 2-bromopropionic acid and ethanol. When catalyzed by acid, the reaction is reversible; when catalyzed by base, the hydrolysis is relatively complete, and carboxylic salts and alcohols are obtained. This is the general property of ester hydrolysis.
At the same time, the α-hydrogen of ethyl 2-bromopropionic acid has a certain acidity. Due to the electron-absorbing action of carbonyl and bromine atoms, hydrogen on α-carbon is easier to leave. Under the action of strong bases, carbon negative ions can be formed, and then participate in reactions such as alkylation. It is an important reaction check point in the organic synthesis step of building carbon-carbon bonds.
Its chemical properties make it widely used in the field of organic synthesis, and it can prepare various organic compounds with different functions through a variety of reaction paths.
What are the main uses of Ethyl 2-Bromopropionate?
Ethyl 2 - Bromopropionate, the Chinese name for ethyl 2 - bromopropionate, its use is unknown, and it is described in ancient and elegant words.
First, in the field of synthesis, this compound is often used as an important raw material. With its unique characteristics, it can be used to generate many complex compounds with specific functions. For example, the interaction of the nuclear phase allows the bromine atom to be placed, and the new carbon-carbon or carbon-atom can be synthesized.
Second, in the synthesis of compounds, it also has a low value. Chemical researchers can use it to introduce specific bases, such as the activity and solubility of chemical molecules. Or in the process, a series of anti-chemical compounds with effective chemical components can be used to help the development of the work, so as to save the world.
Third, in the field of materials science, there are also some improvements. Some polymeric reactions can be made, or modified, so that the material can obtain better mechanical properties, chemical resistance and other characteristics, so as to meet the stringent requirements of material properties in different fields, and is widely used for the improvement of general materials.
In addition, Ethyl 2-Bromopropionate plays an indispensable role in many important fields such as chemical synthesis, chemical research, and materials research, and is an important compound in the chemical field.
What is the synthesis method of Ethyl 2-Bromopropionate?
The synthesis of ethyl 2 - bromopropionate (ethyl 2 - bromopropionate) is an important task in organic synthesis. The method is as follows:
First, propionic acid is used as the starting material, and propionic acid can be obtained by oxidation of propionic aldehyde. The preparation of propionic aldehyde is often made of propylene as the raw material by catalytic hydroformylation. After obtaining propionic acid, it is esterified with ethanol under the catalysis of concentrated sulfuric acid. This esterification reaction requires heating and constant boiling reflux to promote it to proceed in the direction of ester formation. The reaction equation is: $CH_ {3} CHBrCOOH + C_ {2} H_ {5} OH\ underset {\ Delta} {\ overset {H_ {2} SO_ {4}} {\ rightleftharpoons}} CH_ {3} CHBrCOOC_ {2} H_ {5} + H_ {2} O $.
However, the direct esterification method, the yield may not be ideal. Another method is to convert propionic acid to propionyl chloride first. Propionic acid reacts with dichlorosulfoxide to obtain propionic chloride. The reaction is violent and the resulting gases (sulfur dioxide and hydrogen chloride) are easy to escape, pushing the reaction to the right. The equation is: $CH_ {3} CH_ {2} COOH + SOCl_ {2}\ longrightarrow CH_ {3} CH_ {2} COCl + SO_ {2}\ uparrow + HCl\ uparrow $.
After obtaining propionyl chloride, it reacts with ethanol to form ethyl propionate. Subsequently, ethyl propionate is brominated under appropriate conditions. Ethyl 2 - Bromopropionate is obtained by heating the reaction in an inert solvent such as carbon tetrachloride in the presence of an initiator such as benzoyl peroxide. This bromination reaction has good selectivity and can mainly introduce bromine atoms at the alpha-position. In summary, the synthesis of Ethyl 2-Bromopropionate can be carried out through the above steps, depending on factors such as raw material availability, reaction conditions and yield.
What are the precautions when storing Ethyl 2-Bromopropionate?
Ethyl 2-bromopropionate is an organic compound. When storing, many matters need to be paid attention to.
First, a suitable storage environment must be selected. This substance should be stored in a cool and ventilated warehouse. Because the temperature is too high, or its volatilization is intensified, and even chemical reactions are caused; poor ventilation, it is easy to accumulate volatile gases, increasing the risk of fire and explosion.
Second, the integrity of the package must also be strictly checked. The package must be sealed to prevent it from coming into contact with air, moisture, etc. If the package is damaged, moisture intrusion, or hydrolysis reaction occurs, which will damage its quality.
Third, when storing, it should be stored separately from oxidants, alkalis, etc. Because ethyl 2-bromopropionate meets the oxidant, or causes a violent oxidation reaction; contact with alkalis, it is also easy to cause chemical reactions such as hydrolysis, which will affect its chemical properties and quality.
Fourth, in the warehouse, fire and explosion protection measures are essential. Because of its certain flammability, it is likely to encounter open flames, hot topics or explosions. Therefore, fireworks should be prohibited in the warehouse, and fire equipment should be prepared.
Fifth, the storage area should be clearly marked. Indicate the name, characteristics, danger warnings and other information of the substance so that the staff can know that the operation can be carried out in accordance with regulations to avoid accidents.
In addition, it is also necessary to regularly check the stored ethyl 2-bromopropionate. Check its appearance for changes, and check its quality indicators to ensure that its properties are stable and not deteriorated due to storage conditions. In this way, ethyl 2-bromopropionate must be properly stored to ensure its safety and quality.
What is the market price range for Ethyl 2-Bromopropionate?
The market price range of Ethyl 2 - Bromopropionate (ethyl 2 - bromopropionate) varies due to many factors. This compound is often used in organic synthesis and is circulated in the chemical raw material market.
In the past, its price was determined by raw material costs, production processes, supply and demand trends, etc. If the supply of raw materials is sufficient and the production process is mature, the price may stabilize.
At the level of small-scale experimental reagents, the price may be higher. Because the preparation requires specific technology and equipment, and small-scale production is difficult to achieve scale benefits. Usually the price per gram may range from a few to tens of yuan.
In large-scale industrial-grade transactions, the price is mostly measured in tons. If the market demand is strong and the production supply is limited, the price per ton may be in the tens of thousands of yuan; conversely, if the market is saturated, the price may be reduced, or around 10,000 yuan per ton, or even lower, depending on the actual market situation.
Its price often fluctuates with the market. If you want to know the exact price, you should consult the relevant chemical product suppliers or market trading platforms to obtain the latest price information.