Qiji Chemical
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Ethyl Bromoacetate

Qiji Chemical

Ethyl Bromoacetate
Specifications

HS Code

287567

Chemical Formula C4H7BrO2
Molar Mass 167.00 g/mol
Appearance Colorless to light yellow liquid
Odor Pungent, fruity odor
Density 1.50 g/cm³
Boiling Point 158 - 160 °C
Melting Point -38 °C
Solubility In Water Slightly soluble
Solubility In Organic Solvents Soluble in ethanol, ether, chloroform
Flash Point 54 °C
Hazard Class 6.1 (Toxic, flammable)
Packing & Storage
Packing Ethyl Bromoacetate in 500 - mL glass bottle, well - sealed for chemical storage.
Storage Ethyl bromoacetate should be stored in a cool, well - ventilated area away from heat, sparks, and open flames. It should be kept in a tightly - sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, bases, and other reactive chemicals to prevent dangerous reactions. Regularly check for any signs of leakage.
Shipping Ethyl Bromoacetate is a hazardous chemical. It must be shipped in accordance with strict regulations. Use appropriate packaging to prevent leakage. Mark containers clearly, and ensure carriers are trained in handling such chemicals.
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Ethyl Bromoacetate Ethyl Bromoacetate
General Information
Historical Development
"The History of Ethyl Bromoacetate"
Ethyl Bromoacetate is an important organic product. At the beginning, chemists studied physical properties and studied their reasons. In the past, this quality was first obtained. At that time, the technique was not refined, the purification was difficult, and the yield was quite small.
However, science has evolved, and the process has changed day by day. It was difficult to make in the past, and it has gradually become easy to do. Products that were experimented with in the past can now be mass-produced. Chemists use it as a basis to study reactions and expand their uses. In the field of medicine, it helps preparations; in the field of materials, it also contributes.
Over the years, the deeper the understanding of Ethyl Bromoacetate, the wider the application. Rarely used since the beginning, it is indispensable to this day, which is actually the contribution of scientific development. The progress of chemistry is also a lesson for future generations who study new things.
Product Overview
Product Overview of Ethyl Bromoacetate
Ethyl bromoacetate is an important raw material for organic synthesis. Its properties are colorless to yellow clear liquid, with pungent odor, soluble in organic solvents such as ethanol and ether.
This product is often used in the synthesis of various pharmaceutical intermediates in the field of medicine, and has made great contributions to the creation of specific therapeutic agents. In the manufacture of pesticides, it is also a key ingredient, helping to synthesize highly efficient and low-toxic pesticides.
Preparation of ethyl bromoacetate, commonly obtained by the reaction of acetic acid and bromine under the action of a catalyst and then esterified. However, the production process needs to carefully control the reaction conditions to ensure the purity and yield of the product.
When using and storing ethyl bromoacetate, be sure to pay attention to safety. Due to its corrosive and irritating nature, the operation should be well ventilated and wear appropriate protective equipment. Store in a cool, dry and ventilated place away from fire and heat sources to prevent danger.
Physical & Chemical Properties
Ethyl Bromoacetate is an organic compound. It has a colorless to light yellow liquid shape and a pungent odor. Its boiling point is about 159-160 ° C, its density is higher than that of water, and it can be miscible with organic solvents such as ethanol and ether. In terms of chemical properties, it contains bromine atoms and ester groups, so it has the characteristics of halogenated hydrocarbons and esters. Bromine atoms are active and prone to nucleophilic substitution reactions. If they react with nucleophiles such as alcohols and amines, new compounds can be formed. Ester groups can be hydrolyzed, alcoholysis, etc. In terms of physical properties, its volatility is moderate, and it is often used as an alkylating agent in the field of organic synthesis to introduce bromoacetyl groups. It is widely used in the preparation of drugs, fragrances, etc. It is actually an important raw material in organic synthesis.
Technical Specifications & Labeling
"Technical Specifications and Labeling of Ethyl Bromoacetate (Commodity Parameters) "
Ethyl Bromoacetate is an important chemical product. Its technical specifications are quite critical. Looking at its properties, it is a colorless to light yellow transparent liquid at room temperature, with a special odor. The boiling point is about 159-162 ° C, and the density is about 1.506-1.516g/cm ³.
Its logo should also be clear. On the package, the warning words such as "toxic" and "flammable" should be clearly marked to indicate its danger. In terms of commodity parameters, the purity should be above 98%, and the moisture content should not exceed 0.1%. These technical specifications and markings (commodity parameters) are designed to ensure the safety and quality of Ethyl Bromoacetate during production, storage, and use.
Preparation Method
The method of making Ethyl Bromoacetate, the first raw material and the production process. Take ethanol and bromoacetic acid, and the two are in an appropriate ratio, as the basis of the reaction. The reaction step is to first catalyze ethanol and bromoacetic acid in a specific container. This catalytic mechanism needs to be carefully adjusted to promote the smooth reaction.
Under suitable temperature and pressure, the two gradually react. In the meantime, closely observe and control the reaction rate. After the reaction is completed, the impurities are removed through the purification process to obtain pure Ethyl Bromoacetate. The process of production, the selection of raw materials, the control of the reaction, and the method of purification are all related to the quality of the product, and care must be taken to obtain good products.
Chemical Reactions & Modifications
Taste the industry of chemical industry, focusing on the change of things, especially the production of Ethyl Bromoacetate. The method of reaction is related to the essence of chemical industry. The method of the past may have complicated disadvantages, and the yield is not high.
At the beginning of the reaction, the ratio of raw materials and the temperature of the reaction are all key. The previous operation failed to accurately control it, resulting in unsatisfactory reactions. If the temperature is high or low, the difference is insignificant, it is a thousand miles, or there are many side reactions, and the purity of the product is also disturbed by it.
Today, we strive to change it, and improve the process with scientific methods. Carefully study the nature of raw materials and accurately mix them to ensure that the reaction is complete. The technique of temperature control must also be refined to achieve a stable environment. If so, the efficiency of the reaction is greatly increased, the yield of Ethyl Bromoacetate is increased, and the quality is also good. This is the evolution of chemistry. In response to changes, products can be adapted to all needs, adding help to industry and industry.
Synonyms & Product Names
Ethyl Bromoacetate is an important raw material for organic synthesis. Its synonymous name is ethyl bromoacetate. In the chemical industry, it has a wide range of uses.
In the past, chemists worked hard to study this substance. The method of its preparation has undergone several generations of evolution. At first, the preparation was difficult and the yield was not high. After being improved by various scholars, it has gradually improved.
In the field of commerce, ethyl bromoacetate is also circulated under a variety of trade names. Different manufacturers, or according to their own characteristics, have unique names. However, its essence is this Ethyl Bromoacetate.
Today, Ethyl Bromoacetate plays a key role in the pharmaceutical, pesticide and other industries. Although their synonymous names and trade names are different, their functions are the same, promoting the vigorous development of the chemical industry and laying a solid foundation for progress in many fields.
Safety & Operational Standards
Code for the safe production and operation of ethyl bromoacetate
For ethyl bromoacetate, it is also a commonly used reagent for organic synthesis. However, it is toxic and corrosive, and it is related to safe production and standardized operation. It should not be ignored.
#1. Storage rules
should be placed in a cool and ventilated warehouse, away from fire and heat sources. The warehouse temperature should not exceed 30 ° C, and keep the container sealed. It should be stored separately from oxidants, alkalis, and edible chemicals, and should not be mixed. The storage area should be equipped with leakage emergency treatment equipment and suitable containment materials to prevent leakage.
#2. Operation essentials
Operators must undergo special training and strictly abide by the operating procedures. When operating, you need to wear a self-priming filter gas mask (half mask), wear chemical safety glasses, wear anti-poison penetration work clothes, and wear rubber oil-resistant gloves to protect your own safety.
The operation site should be kept away from fire and heat sources, and smoking is strictly prohibited in the workplace. Use explosion-proof ventilation systems and equipment to prevent steam leakage into the air of the workplace. Avoid contact with oxidants and alkalis. When filling, the flow rate should be controlled, and there should be a grounding device to prevent static electricity accumulation. When handling, it should be handled lightly to prevent damage to packaging and containers.
#3. Emergency measures
If you accidentally come into contact with the skin, you should immediately take off the contaminated clothes, rinse with a lot of flowing water for at least 15 minutes, and then seek medical attention. In case of eye contact, the eyelids should be lifted immediately, rinsed thoroughly with plenty of flowing water or normal saline for at least 15 minutes, and medical attention is also required.
If inhaled, quickly leave the scene to a fresh place of air to keep the respiratory tract unobstructed. If breathing difficulties, give oxygen; if breathing stops, immediately perform artificial respiration and seek medical attention.
If ingested, drink enough warm water, induce vomiting, and seek medical attention.
In the event of a leak, personnel from the contaminated area of the leak should be quickly evacuated to a safe area, and quarantined to strictly restrict access. Cut off the source of fire. It is recommended that emergency personnel wear self-contained positive pressure breathing apparatus and anti-toxic clothing. Do not directly contact the leak. Cut off the source of the leak as much as possible. Prevent flow into restricted spaces such as sewers and drainage ditches. Small Leaks: Adsorb or absorb with sand or other non-combustible materials. Large Leaks: Build embankments or dig pits for containment. Cover with foam to reduce vapor hazards. Transfer to tank cars or special collectors with explosion-proof pumps for recycling or transportation to waste disposal sites.
Application Area
Ethyl Bromoacetate is also a chemical material, and it can be used. In the field of medicine, it can be synthesized into raw materials. Such as a certain pain, and other substances can be combined to form the required effective ingredients.
In the field of medicine, it can be used to make a good product. It can be harmful like catching or poisoning, which will ensure the safety of crops and ensure the safety of harvests.
And in the field of spices, it can be used to help the fragrance. The combination of the raw materials of the fragrance, the spice is special, making it fragrant and charming.
And there is a synthesis problem, which is important. There are various kinds of assistants. There are many steps to promote the research of chemistry, and the way to use it.
Research & Development
My research on Ethyl Bromoacetate has been going on for many years. This compound has unique properties and a wide range of uses, which is especially crucial in the field of organic synthesis.
At the beginning, I explored the method of its preparation, but it has been tested many times and encountered many difficulties. The proportion of raw materials and the conditions of the reaction all need to be fine-tuned, and if there is a slight difference, the results will be very different. However, after unremitting research, I finally obtained a stable method, and the yield gradually improved.
Then, after observing its reaction characteristics, it can show unique activities in many chemical reactions. Based on this, it has expanded its application scope and has been tried in medicine, materials, etc.
Today, the research of Ethyl Bromoacetate is still ongoing. It is hoped that in the future, we can gain deeper insight into its essence, explore new uses, and make greater progress in scientific research and industry, contributing to the academic community and the industry.
Toxicity Research
Ethyl Bromoacetate is a chemical substance that has been studied in modern times. I have devoted myself to studying its toxicity for a long time.
Ethyl Bromoacetate has strong irritating properties. When it touches the body and skin, it can cause burning pain, redness and swelling, and even skin ulceration is difficult to heal. If it enters the eyes, it will harm the eyes, or cause damage to the eyesight, and the consequences will be disastrous. Its breath is pungent, inhaled into the lungs, disturbs the way of breathing, causes coughing, asthma, and damages the function of the lungs.
After repeated tests, this substance can disrupt the physiological order of the living body. It may harm the metabolism of cells, or interfere with the transcription of genes. Although the amount is different, it should not be ignored. In order to prevent its harm, those who operate this thing should strictly abide by the regulations, wear protective equipment, and do it in a well-ventilated place. Make sure it doesn't leak out to protect everyone's health and the environment is peaceful.
Future Prospects
I try to research Ethyl Bromoacetate, which is used in today's chemical industry and has a wide range of uses. However, today's production methods have many shortcomings, energy consumption is quite large, and harmful side effects may be produced in production, polluting the environment.
Looking to the future, I hope to create a green production method. With new catalytic techniques, energy consumption can be reduced, pollution can be reduced, and production can be cleaner and more efficient. Or mild reaction conditions can be found to avoid strong acid and alkali and high temperature and pressure, to protect equipment and improve safety.
Furthermore, hope to expand its application. Nowadays, it is mostly used in medicine and pesticides. In the future or in the production of new materials, it will emerge, contributing to the advancement of science and technology. Such as assisting in the research of new functional materials, to meet the needs of electronics and energy. I believe that with time, Ethyl Bromoacetate will shine brightly and expand into the future.
Frequently Asked Questions
What are the main uses of Ethyl Bromoacetate?
Ethyl bromoacetate has a wide range of main uses. In the field of organic synthesis, it is often used as a key reagent. It can be used to prepare many organic compounds with special structures and functions, such as the synthesis of certain pharmaceutical intermediates, which plays an important role in the development and production of medicines. Through specific chemical reactions, it can cleverly construct specific structural fragments of drug molecules and help create new drugs.
In the field of pesticides, it also has significant uses. It can be used as a key raw material for the synthesis of specific pesticides, contributing to the improvement of the efficacy and selectivity of pesticides. Through chemical synthesis, it is converted into pesticide ingredients with high-efficiency insecticidal, bactericidal or herbicidal activities to ensure the growth and yield of crops.
In the field of materials science, ethyl bromoacetate also plays an important role. It can participate in the synthesis of some polymer material monomers, laying the foundation for the research and development of new materials with unique properties. Through careful design of chemical reactions, using its reactive groups, polymer materials have better mechanical properties, thermal stability or special optical and electrical properties, etc., to meet the diverse needs of materials in different fields.
In addition, in the preparation of fine chemical products, ethyl bromoacetate is also indispensable. It can be used to synthesize fine chemicals such as fragrances and dyes, giving products a unique aroma or color, and satisfying people's pursuit of the quality of these fine chemical products in daily life and industrial production. In short, ethyl bromoacetate plays an irreplaceable role in many important fields due to its unique chemical properties, promoting the development and progress of related industries.
What are the physical properties of Ethyl Bromoacetate?
Ethyl bromoacetate is one of the organic compounds. It has unique physical properties and is worth exploring.
Looking at its properties, it is a colorless to light yellow transparent liquid at room temperature. It is like a quiet water, but it contains chemical mysteries. Its smell is unique and slightly irritating, just like a slightly pungent breeze, which can cause people to be alert.
As for the boiling point, it is between 158 and 160 degrees Celsius. When the temperature gradually rises, ethyl bromoacetate changes from liquid to gaseous like a butterfly, showing the wonderful transformation of material state. Its density is about 1.506g/cm ³, which is heavier than water. If it is placed in one place with water, it will be like a sunken stone entering the water and quietly living in the lower layer.
Solubility is also an important property. Ethyl bromoacetate is soluble in many organic solvents, such as ethanol, ether, etc., just like fish entering water and fusing with it. However, its solubility in water is quite limited, as if there is an invisible barrier between water and it, and it can only be slightly dissolved.
In addition, the refractive index of ethyl bromoacetate also has its specific value, about 1.4501. When light passes through, it will be refracted according to this specific law, just like light performing a unique dance in it, presenting a subtle scene of matter acting on light. These physical properties are of great significance in the fields of chemical research and industrial applications, providing a key basis for the development of related operations and reactions.
Chemical Properties of Ethyl Bromoacetate
Ethyl bromoacetate (ethyl bromoacetate) is an important compound commonly used in organic synthesis and has many unique chemical properties.
First, it has the typical properties of halogenated alkanes. The bromine atom in its molecule has high activity and is prone to nucleophilic substitution reaction. Because the bromine atom is electronegative, and the bond connected to the carbon atom has a certain polarity, the carbon atom is partially positively charged and vulnerable to nucleophilic attack. In case of alcohol nucleophilic reagents, the bromine atom can be replaced by an alcoholoxy group to form corresponding ester compounds; if it interacts with amine nucleophilic reagents, it will form nitrogen-containing substitution products. This nucleophilic substitution reaction is widely used in organic synthesis reactions to construct carbon-heteroatom bonds.
Second, its ester group also has specific reactivity. Under basic conditions, hydrolysis can occur. Hydroxide ions attack the carbonyl carbon atom of the ester group and are converted through a series of intermediates to eventually produce bromoacetic acid and ethanol. If this hydrolysis reaction is controlled, it can be used to prepare bromoacetic acid. And under specific conditions, ester groups can also participate in ester exchange reactions, that is, exchange alkoxy groups with other alcohols under the action of catalysts to form new esters.
Third, because the bromine atom is adjacent to the ester group, the two interact to change the overall reactivity of the molecule. This structural feature allows Ethyl Bromoacetate to participate in some unique reaction pathways, such as in some metal-catalyzed reactions, through the selective conversion of bromine atoms and ester groups, to construct complex organic molecular structures, which are important in drug synthesis, material chemistry, and other fields.
Ethyl Bromoacetate in Storage and Transportation
In the case of ethyl bromoacetate, many matters must be paid attention to during storage and transportation.
The first thing to pay attention to is its storage environment. Ethyl bromoacetate is flammable and corrosive, and should be placed in a cool, dry and well-ventilated place. This is due to high temperature, humidity, or increased volatilization, and even chemical reactions, endangering safety. And it is necessary to keep away from fire and heat sources to prevent the risk of fire and explosion.
Furthermore, storage containers are also critical. Corrosive-resistant materials, such as glass or specific plastic containers, should be used, and they must be tightly sealed to prevent their volatilization from contacting air and moisture. Because ethyl bromoacetate is exposed to water or moisture, it is easy to hydrolyze, which will damage its quality and performance.
As for transportation, the packaging must be compliant to ensure stability and prevent damage and leakage of the container due to bumps and collisions. During handling, operators must be cautious and wear appropriate protective equipment, such as protective clothing, gloves, goggles, etc., because these objects come into contact with the skin and eyes, which can cause burns.
Transportation vehicles should also be selected with fire and explosion-proof facilities, and transportation routes should be planned to avoid crowded areas and important facilities. If there is a leak during transportation, emergency measures should be taken immediately, evacuate the surrounding personnel, seal off the scene, and clean up and dispose of it by professional means to prevent the spread of hazards.
In this way, the storage and transportation of ethyl bromoacetate should be carried out with caution and attention to all details, so that security is safe.
What are the synthesis methods of Ethyl Bromoacetate?
The method of preparing ethyl bromoacetate has been described in many books in the past, and the following are common preparation methods.
First, ethyl acetate is used as the starting material and halogenated. Ethyl acetate is mixed with bromine under the action of a suitable catalyst. Phosphorus trichloride or red phosphorus is often used as the catalyst. Under heating conditions, bromine atoms can replace α-hydrogen atoms in ethyl acetate to form ethyl bromoacetate. This process requires precise control of the reaction temperature and the amount of bromine. If the temperature is too high, it is easy to form polyhalogenated by-products; improper bromine dosage also affects the purity and yield of the product.
Second, ethanol and bromoacetic acid are used as raw materials and obtained by esterification. Take an appropriate amount of ethanol and bromoacetic acid, add concentrated sulfuric acid as a catalyst, and add a little zeolite to prevent boiling. Under the condition of heating and reflux, the hydroxyl group of ethanol and the carboxyl group of bromoacetic acid are esterified to form ethyl bromoacetate and water. After the reaction is completed, the product needs to be purified through the steps of neutralization, washing with water, drying, and distillation. During neutralization, an appropriate amount of sodium bicarbonate solution should be used to remove the residual sulfuric acid; washing with water is designed to remove soluble impurities; desiccants such as anhydrous magnesium sulfate can be used in the drying process; distillation can obtain pure ethyl bromoacetate.
Third, react with bromine and vinyl ethyl acetate. The addition reaction of bromine and vinyl ethyl acetate is carried out in an inert solvent at a suitable temperature and in the presence of a catalyst. The reaction conditions are relatively mild, but the purity of the raw materials is quite high, and the reaction process needs to be carefully controlled to ensure the quality of the product.
All production methods have their own advantages and disadvantages. In actual operation, when considering factors such as the availability of raw materials, cost, and purity requirements of the product, the most suitable method is selected.