Qiji Chemical
Products

Ethyl Bromoacetate

Qiji Chemical

Specifications

HS Code

102044

Chemical Formula C4H7BrO2
Molar Mass 167.00 g/mol
Appearance Colorless to light - yellow liquid
Odor Pungent, fruity odor
Density 1.509 g/cm³ at 20 °C
Boiling Point 158 - 160 °C
Melting Point -38 °C
Solubility In Water Slightly soluble
Solubility In Organic Solvents Soluble in ethanol, ether, chloroform, etc.
Flash Point 54 °C (closed - cup)
Packing & Storage
Packing Ethyl Bromoacetate in 500 - mL glass bottle, tightly sealed for safe storage.
Storage Ethyl bromoacetate should be stored in a cool, well - ventilated area away from heat, sparks, and open flames as it is flammable. Keep it in a tightly closed container, preferably made of corrosion - resistant materials, to prevent leakage. Store it separately from oxidizing agents, bases, and reactive metals to avoid dangerous reactions.
Shipping Ethyl Bromoacetate is shipped in tightly - sealed containers, compliant with hazardous material regulations. It's transported with care due to its toxic and flammable nature, often via ground or sea freight with proper safety measures.
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General Information
Frequently Asked Questions
What are the main uses of Ethyl Bromoacetate?
Ethyl bromoacetate is widely used. In the field of organic synthesis, it is often a key raw material. For example, in drug synthesis, it can be used as an important intermediate to help build the specific structure of drug molecules to achieve the desired pharmacological effect. The preparation of many antibiotics, analgesics and other drugs depends on its participation in the reaction.
In the manufacture of pesticides, ethyl bromoacetate also plays a key role. It can be converted into compounds with insecticidal, bactericidal or herbicidal activities through specific chemical reactions, contributing to the control of pests and weeds in agricultural production, and improving crop yield and quality.
In the field of materials science, it can be used to synthesize materials with special properties. For example, participating in the preparation of certain polymers imparts unique physical and chemical properties to materials, such as improved material solubility and stability, to meet the needs of different industrial scenarios.
Furthermore, in the synthesis of fine chemical products, ethyl bromoacetate is also a commonly used reagent. In the synthesis path of many fine chemicals such as fragrances and dyes, it participates in a series of chemical reactions as a reaction substrate or intermediate, promoting the preparation and research and development of products, enriching the types of fine chemical products, and meeting the diverse needs of the market.
What are the physical properties of Ethyl Bromoacetate?
Ethyl bromoacetate is an organic compound. It has specific physical properties, which are described as follows:
Looking at its properties, under normal conditions, ethyl bromoacetate is a colorless to light yellow transparent liquid, clear and has a special smell, and its unique smell can be distinguished by the smell.
When it comes to density, it is about 1.506g/cm ³, which is heavier than water. When placed in water, it must sink at the bottom. Its boiling point is between 158 and 160 ° C. When heated to this temperature range, it gradually changes from liquid to gaseous and evaporates.
As for the melting point, about -20 ° C, the temperature drops to Si, and the substance solidifies from liquid to solid. The solubility of
ethyl bromoacetate is also an important physical property. It is soluble in many organic solvents, such as ethanol, ether, etc., and is miscible with them. However, its solubility in water is poor, and it is difficult to blend with water.
And its refractive index is about 1.452-1.454. When light passes through this substance, its refraction degree is characterized by this numerical value. This number is of great significance for the identification and analysis of this compound. The above physical properties are all key elements for the understanding and study of ethyl bromoacetate.
Chemical Properties of Ethyl Bromoacetate
Ethyl bromoacetate (ethyl bromoacetate) is also an organic compound. It has active chemical properties and can be used as a key raw material in many chemical reactions.
This substance has the dual characteristics of halogenated alkanes and esters. Its halogen atom (bromine) is very active and prone to nucleophilic substitution reactions. For example, when it encounters nucleophilic reagents such as alcohols, phenols, and amines, bromine atoms can be substituted to form corresponding ethers, esters, and amides. This substitution reaction is a common means of forming carbon-heteroatomic bonds in organic synthesis.
And because it contains ester groups, it can also participate in typical reactions of esters. Such as hydrolysis, under acidic or basic conditions, ester groups can be hydrolyzed to carboxyl groups and alcohols. In alkaline hydrolysis, the reaction is more thorough, resulting in bromoacetate and ethanol; in acidic hydrolysis, bromoacetic acid and ethanol can be obtained.
In addition, Ethyl Bromoacetate can participate in the condensation reaction. Under appropriate catalysts and reaction conditions, it can condensate with compounds containing active hydrogen, such as ketones and aldose, and introduce specific structural fragments into organic molecules, thereby expanding the complexity and diversity of molecules. It is widely used in drug synthesis, total synthesis of natural products and other fields.
Its chemical properties are active, making it an important tool for organic synthesis chemistry. However, due to its activity, it is necessary to pay attention to the precise control of reaction conditions when using it to achieve the desired synthesis goal.
What should Ethyl Bromoacetate pay attention to when storing?
In the presence of ethyl bromoacetate, it is also necessary to dispose of chemical substances.

In the first heavy environment. It should be stored in a place that is dry, dry and well-connected. This is because if the environment is high, damp, or chemically sensitive, there is also a risk of explosion. High temperature can promote it to burn, gather in a limited space, and it is easy to cause burning in case of open fire; damp or hydrolytic isochemical reaction, and its degree.
The second word is the container. A sealed and corrosion-resistant device must be used. The seal can be used to prevent it from being damaged outside, so as to prevent it from being damaged in the air. Ethyl bromoacetic acid ester is active, easy to cause multiple chemical reactions. If it is incompatible, it may be damaged. And it is corrosive, so it needs a corrosion-resistant device to prevent the container from being damaged and leaking.
Furthermore, if it is not stored, it will cause ignition, oxidation and oxidation. This is because it is flammable, in case of fire or high temperature, it will ignite immediately, or even explode. Oxidation can also be strong and react, causing danger.
It also needs to be stored separately, and it should not be mixed with alcohol, alcohol, etc. Because of its rapid reaction, the chemicity is changed; alcohol may also have side reactions, which will affect the product.
And the fire protection and leakage emergency management. Once there is a leak, it can be fixed in time and less harmful. Humans are also trained to know its danger and urgent measures to ensure safety.
What are the synthesis methods of Ethyl Bromoacetate?
The method of preparing ethyl bromoacetate has been used in ancient times. In the past, there were mostly methods of combining brominating agents with ethyl acetate. Common brominating agents, such as bromine, are also. At the time of reaction, first place ethyl acetate in a suitable container, slowly add bromine dropwise, and at the same time apply moderate heating and stirring to promote its full reaction. This process needs to pay attention to the control of the reaction temperature. If it is too high, it is easy to cause side reactions, and if it is too low, the reaction will be slow.
There is also a method of combining ethanol and bromoacetic acid. Put ethanol and bromoacetic acid in an appropriate ratio in the reaction kettle, and add an appropriate amount of catalyst, such as sulfuric acid, to accelerate the reaction process. When reacting, it is necessary to pay attention to removing the water generated by the reaction, which can be achieved by azeotropic distillation, etc., which can promote the reaction to form ethyl bromoacetate.
There are also those prepared by the substitution reaction of halogenated hydrocarbons. Select a suitable halogenated hydrocarbon, such as chloroethyl acetate, and make it react with the brominating agent under appropriate conditions, and the bromine atom replaces the chlorine atom to obtain ethyl bromoacetate. In this process, the regulation of the reaction conditions is very critical, such as the reaction temperature, reaction time, and the ratio of the reactants, which all have a significant impact on the yield and purity of the product.
All methods have their own advantages and disadvantages, and it is necessary to carefully choose the appropriate preparation method according to the specific conditions, such as the availability of raw materials, cost considerations, and product purity requirements, in order to obtain satisfactory results.