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Isopropyl 2-Bromo-2-Methylpropanoate

Qiji Chemical

Isopropyl 2-Bromo-2-Methylpropanoate
Specifications

HS Code

543174

Name Isopropyl 2-Bromo-2-Methylpropanoate
Chemical Formula C7H13BrO2
Molar Mass 209.08 g/mol
Appearance Colorless to pale yellow liquid
Boiling Point Approximately 185 - 187 °C
Density Around 1.24 g/cm³
Solubility Slightly soluble in water, soluble in organic solvents
Flash Point Approx. 75 °C
Odor Characteristic odor
Stability Stable under normal conditions but may react with strong oxidizing agents
Packing & Storage
Packing Isopropyl 2 - Bromo - 2 - Methylpropanoate, 500g, in sealed, chemical - resistant glass bottle.
Storage Isopropyl 2 - Bromo - 2 - Methylpropanoate should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly - sealed container to prevent vapor leakage. Store it separately from oxidizing agents, reducing agents, and bases as it may react with them. The storage area should be clearly marked and accessible only to authorized personnel.
Shipping Isopropyl 2 - Bromo - 2 - Methylpropanoate is shipped in sealed, corrosion - resistant containers. It's transported under regulated conditions, following hazardous chemical shipping guidelines to prevent leakage and ensure safety during transit.
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Isopropyl 2-Bromo-2-Methylpropanoate Isopropyl 2-Bromo-2-Methylpropanoate
General Information
Historical Development
Hearing the goodness of ancient times is also to learn, to study the physical properties, to observe the micro-knowledge. Today there is a thing named Isopropyl 2 - Bromo - 2 - Methylpropanoate. Scholars have devoted themselves to the study of its origin. At the beginning of the time, they did not know much about it, but only knew a little about its characteristics.
Delayed over the years, the wise men devoted themselves to the study of its structure and properties. From simple observation, gradually to precise experiment. At first, we can only analyze its general composition, and later we can understand the micro-mystery of its molecular structure.
Everyone moved forward with great effort, and their techniques became more and more exquisite. In the past, we only relied on conventional methods, but now we use high-tech techniques to explore its reaction mechanism and understand its law of change. It is gradually recognized by the world for its use, and has emerged in various fields, from the development of medicine to the synthesis of materials. This is the fruit of the efforts of the sages, and it is also a chapter of academic evolution. Future generations will continue to open up, explore its subtleties, and do their best to benefit the world.
Product Overview
Product Overview
Today there is a product called Isopropyl 2 - Bromo - 2 - Methylpropanoate (Isopropyl 2 - Bromo - 2 - Methylpropanoate). This is an organic compound with a unique molecular structure, containing bromine atoms and isopropyl, methyl and propionate ester groups.
From the appearance point of view, at room temperature and pressure, it is often colorless to light yellow liquid-like, with a clear texture, or a faint luster under light. Its smell has a special organic compound smell, which is not pungent but can attract attention.
It talks about properties and has certain chemical activity. Bromine atoms are active and can participate in many nucleophilic substitution reactions. In the field of organic synthesis, it is often a key starting material for the construction of new carbon-carbon bonds or carbon-heteroatomic bonds. Its propionate group can also undergo hydrolysis, alcoholysis and other reactions under specific conditions, giving this substance a variety of uses in chemical synthesis, and is of great value in the synthesis of pharmaceutical intermediates and the preparation of fine chemicals.
Physical & Chemical Properties
Today there is a thing called Isopropyl 2 - Bromo - 2 - Methylpropanoate. It has physical and chemical properties, and I have investigated it in detail.
Looking at its physical properties, at room temperature, this substance has a specific shape, or is liquid, has its own unique color, or is clear and transparent, or is slightly dyed. Smell it, it has a special smell, or it is thin or light, and your mileage may vary. Its density value is exact, it is related to the state of sinking and floating. And the boiling point and melting point are fixed, and under different temperature conditions, the shape changes in an orderly manner.
On its chemical properties, the molecular structure is exquisite, and the atomic arrangement is orderly. This structure determines its chemical activity. In case of a specific reagent, a chemical reaction occurs, or bonds are broken, or new bonds are formed, and the products are different. It can participate in esterification and substitution reactions, and has a wide range of uses in the field of organic synthesis. It can be the cornerstone of building complex compounds and is of great value in the chemical industry and scientific research.
Technical Specifications & Labeling
There are chemical products today, called Isopropyl 2 - Bromo - 2 - Methylpropanoate. Its process specifications and identification (commodity parameters) are crucial to the quality and use of this material.
The process specifications of the husband, from the selection of raw materials, the precision of the ratio, to the temperature and time of the reaction, all have a fixed number. The raw materials must be pure, the ratio must be accurate, the reaction temperature should be constant, and the length of time should be appropriate, so as to obtain good quality products.
And the identification (commodity parameters) clearly indicates its materialization properties, such as color, taste, state, fusion, boiling point, and the number of purity and content. This is all the evidence for the user to distinguish its good and bad and determine its suitability.
All these process specifications and labels (commodity parameters) are carefully observed by those who make and use this product, and there must be no neglect in order to ensure its quality and safety.
Preparation Method
To prepare Isopropyl 2 - Bromo - 2 - Methylpropanoate, the raw materials and production process are the key. When using isopropyl alcohol and 2 - bromo - 2 - methylpropionic acid as the starting materials.
The reaction steps are as follows: first put the isopropyl alcohol in a clean reactor, and control the temperature in a suitable range, usually about 30 to 40 degrees Celsius. Slowly add 2 - bromo - 2 - methylpropionic acid and stir at the same time to promote full contact between the two. During the reaction process, the reaction rate and direction are regulated with an acid-base catalyst to ensure that the reaction proceeds towards the target product.
The catalytic mechanism is that the catalyst can reduce the activation energy of the reaction, making the molecules more likely to collide effectively. The reaction lasts about 2 to 3 hours, and the reaction can be terminated when the target product content in the reaction solution reaches the expected level. Subsequent purification steps such as distillation and extraction can obtain pure Isopropyl 2 - Bromo - 2 - Methylpropanoate.
Chemical Reactions & Modifications
The technology of chemical engineering is to study the change of substances and seek new substances. It is related to the people's livelihood and national plans. Today, there is a name Isopropyl 2 - Bromo - 2 - Methylpropanoate, and its chemical change and sexual change are the key to our research.
Chemical change, or new product, or change its properties. Isopropyl 2 - Bromo - 2 - Methylpropanoate, its change path, or involving substitution and addition methods. In the change of substitution, the atom or group is translocated, resulting in the change of structure, and the properties follow. If a reagent is used instead, or the halogen atom is easily changed, its reactivity is changed.
As for the change of nature, it is related to its molecular structure and the distribution of electronic clouds. The change of structure makes the physical properties such as the point of melting and boiling, and the dissolution are different; the movement of electronic clouds makes the chemical properties such as nucleophilic and electrophilic. We study it, and hope to understand the law of its change, so as to make good use of it, for the benefit of the chemical industry and the people's livelihood, and to do our best to explore the mystery of chemistry.
Synonyms & Product Names
There is a thing named Isopropyl 2 - Bromo - 2 - Methylpropanoate. This thing is quite useful in various chemical products in this world. It also has many synonymous names and commodity names.
Looking back to the past, when chemical sages studied this product, they gave different synonymous names because of its structure, properties and reactions involved. There are those who are finely named for its chemical structure, in order to accurately describe its composition; there are also different names due to application scenarios or preparation methods.
As for the name of a commodity, merchants want to recognize its characteristics, advantages, or in response to market needs, and name it. This is to make this product easy to recognize, distinguish and apply in the field of chemical industry. Although there are many synonymous names and commodity names, they all refer to this Isopropyl 2 - Bromo - 2 - Methylpropanoate, which has its value in chemical research, industrial preparation and practical use.
Safety & Operational Standards
Safety and Operating Specifications for Isopropyl 2-Bromo-2-Methylpropionate
Isopropyl 2-bromo-2-methylpropionate occupies a place in chemical products. Regarding its safety and operating specifications, it must not be ignored.
This product has certain hazards. Its chemical properties are active, and it may cause combustion and explosion in case of open flames, hot topics or contact with oxidants. Therefore, when storing, it must be placed in a cool and ventilated warehouse, away from fire and heat sources, and should be stored separately from oxidants and alkalis, and should not be mixed with storage. During handling, it should also be handled lightly to prevent damage to packaging and containers.
When operating, the operator must undergo special training and strictly abide by the operating procedures. It is recommended that the operator wear a self-priming filter gas mask (half mask), chemical safety glasses, anti-poison penetration overalls, and rubber oil-resistant gloves for safety.
If you accidentally come into contact with the skin, you should immediately remove the contaminated clothing, rinse with a large amount of flowing water for at least 15 minutes, and then seek medical attention. If it splashes into the eyes, you should immediately lift the eyelids, rinse thoroughly with a large amount of flowing water or normal saline for at least 15 minutes, and seek medical attention in time. If you inhale accidentally, you should quickly leave the scene to a fresh air place to keep the respiratory tract unobstructed. If you have breathing difficulties, give oxygen. If you stop breathing, perform artificial respiration immediately and seek medical attention immediately.
During the preparation and use process, the laboratory or factory should be equipped with the corresponding variety and quantity of firefighting equipment and leakage emergency treatment equipment. In the event of a leak, personnel from the contaminated area of the leak should be quickly evacuated to the safe area, isolated, and strictly restricted access. Emergency personnel need to wear self-contained positive pressure breathing apparatus, wear anti-toxic clothing, and do not let the leakage come into contact with combustible substances (such as wood, paper, oil, etc.). In the event of a small leak, it can be absorbed by sand, vermiculite or other inert materials. Large leaks should be built embankments or dug for containment, covered with foam to reduce steam disasters, and then transferred to a tank or a special collector by pump, recycled or transported to a waste treatment site for disposal.
All of these are standards for the safety and operation of isopropyl 2-bromo-2-methylpropionate, and practitioners must adhere to them to ensure personal and environmental safety.
Application Area
Isopropyl 2-bromo-2-methylpropionate is also a product of organic chemistry. Its application field is worth exploring. In the field of organic synthesis, this compound is often a key intermediate. It can be converted into other types of organic molecules through a specific reaction path, enriching the synthesis strategy.
In the field of medicinal chemistry, it may participate in the construction of drug molecules, giving drugs specific activities and properties through its unique structure. It has also emerged in materials science, helping to synthesize materials with special properties.
Looking at its application, such as a delicate chess game, every step is about the final result. With the help of chemical methods, this compound can open the door to new fields and bloom its unique brilliance in various applications, contributing to the progress of science.
Research & Development
Isopropyl 2 - Bromo - 2 - Methylpropanoate has been studied for years. This compound has a unique structure and different properties, and has great potential in the field of organic synthesis.
At the beginning, the synthesis method was difficult and complicated, and the yield was quite low. However, we have worked tirelessly to explore various paths and explore various conditions. After repeated tests, the process was improved and the steps were optimized. Finally, a good method was found, which gradually increased the yield and improved the quality.
Its application path has also gradually expanded. In the creation of medicine, it can be used as a key intermediate to help the research and development of new agents; in material science, it can contribute to the construction of special materials.
We will continue to study this compound, hoping that in the future, it can contribute to scientific progress and industrial development, and bloom in the path of scientific research.
Toxicity Research
The toxicity of isopropyl 2-bromo-2-methylpropionate is studied in this study. This compound is a commonly used reagent in organic synthesis. Looking at its structure, it contains bromine atoms and ester groups, or has specific chemical activities.
It was observed in animal experiments that mice had drowsiness and decreased activity after oral ingestion. The dissection showed that the color and texture of the liver and kidneys were different from the norm, or the metabolites of the substance affected the function of organs.
The cytotoxicity was also investigated by cell experiments. The compound was added to cultured hepatocytes and kidney cells. At a certain concentration, the cell survival rate decreased and the apoptosis rate increased, indicating that it inhibited and destroyed the physiological activity of cells.
In summary, isopropyl 2-bromo-2-methylpropionate has certain toxicity, and subsequent use and research and development should pay attention to safety protection and study its toxicological mechanism in detail to avoid adverse effects on organisms and the environment.
Future Prospects
Now this Isopropyl 2-Bromo-2-Methylpropanoate is a chemical that we have dedicated ourselves to researching. Although its characteristics and applications have been known at present, the future prospects are still promising.
In the synthesis method, we hope to find a simpler and more efficient way. Reduce complicated steps, improve yield and reduce costs, which may make its large-scale preparation more feasible. The application level may be extended to emerging fields. For example, materials science, with its unique structure, may contribute to the development of new materials. In terms of biomedicine, with exquisite design, it may be a targeted drug carrier for precise treatment.
This chemical will surely shine like a new star in the future, shining brightly in the sky of science, for the well-being of mankind, opening up new frontiers, and leading the ship of science and technology to the unknown but full of hope.
Frequently Asked Questions
What are the chemical properties of Isopropyl 2-Bromo-2-Methylpropanoate?
Isopropyl 2-bromo-2-methylpropionate, this is an organic compound. It is active and has a wide range of uses in the field of organic synthesis.
Looking at its chemical properties, it bears the brunt of the halogenated alkane characteristics. 2-Bromo-2-methylpropionate part, bromine atom activity is very high. In case of nucleophilic reagents, it is easy to initiate nucleophilic substitution reactions. In case of alcohol nucleophilic reagents, the oxygen atom of the alcohol attacks the carbon connected to the bromine with lone pair electrons, and the bromine ion leaves to produce new ester compounds. This reaction is commonly used in organic synthesis to prepare polyester structures. Different alcohol nucleophilic reagents can be used to obtain products with different structures and expand the variety of compounds.
In addition, it has the generality of esters. Under the catalysis of acid or base, it can react hydrolytically. In acidic hydrolysis, in dilute acid solution, water attacks the carbonyl carbon of the ester group, and through a series of proton transfer, the ester bond is broken, and isopropanol and 2-bromo-2-methylpropionic acid are produced. In alkaline hydrolysis, the hydroxide ion has strong nucleophilicity, and quickly attacks the ester carbonyl carbon. The ester bond is also broken, and the product is isopropanol and 2-bromo-2-methylpropionate. This hydrolysis property can be used in organic synthesis for functional group conversion, transforming the ester group into the corresponding acid or alcohol, paving the way for subsequent reactions.
In addition, due to the influence of isopropyl and 2-methyl, the molecular space structure is special, which affects the reactivity and selectivity. In some reactions, the steric hindrance effect is significant. For example, when nucleophilic substitution, isopropyl and methyl hinder the attack of nucleophilic reagents, and the reaction rate is different from that of similar compounds without such substituents. And this space structure also affects its physical properties such as boiling point and melting point. Due to the change of intermolecular forces, the melting boiling point has a unique value.
In summary, isopropyl 2-bromo-2-methylpropionate is an important raw material and intermediate in the field of organic synthesis due to its special structure, active and unique chemical properties, and its characteristics can be used to construct a variety of organic compounds.
What are the common uses of Isopropyl 2-Bromo-2-Methylpropanoate
Isopropyl 2-bromo-2-methylpropionate, its common uses are as follows:
In the field of organic synthesis, it is often used as a key intermediate. Due to its unique structure, the bromine atom and ester group have high reactivity. Taking nucleophilic substitution as an example, the bromine atom can be replaced by many nucleophilic reagents, such as alcohols and amines. If it reacts with alcohols under the catalysis of suitable bases, corresponding ether compounds can be formed. This reaction mechanism is that the nucleophilic test agent attacks the carbon atoms connected to the bromine atom, and the bromine ions leave to form a new carbon-oxygen or carbon-nitrogen bond. This process is similar to the ancient war between two armies, one side occupied the other's position, the old "force" (bromine ion) retreated, and the new "force" (new functional group) settled in.
When building complex organic molecular structures, isopropyl 2-bromo-2-methylpropionate can be connected to other organic fragments through a multi-step reaction. After a series of carefully designed reaction steps, such as hydrolysis and reduction of ester groups, the properties of their functional groups are changed, and then they react with other compounds containing specific functional groups. It is like building a delicate pavilion, using it as a cornerstone, building layers to build complex and functional organic molecules.
In the field of pharmaceutical chemistry, it also has important uses. In some drug development processes, specific structures need to be introduced to optimize the activity, solubility or metabolic properties of drugs. The structural fragments of this compound may be used as components of pharmacophore, or affect the interaction between drugs and targets. For example, the modified derivatives may better fit the activity check point of the receptor, like the precise matching of the key and the lock, enhancing the binding force between the drug and the target, thereby improving the efficacy.
In the field of materials science, it can also play a role. Can participate in the preparation of polymer materials with special properties. By copolymerizing with other monomers, its structural units are introduced into the main chain or side chain of the polymer, giving the polymer material special properties, such as improving the solubility and thermal stability of the material. It is like injecting a unique "soul" into the material, making it have unique characteristics to meet the special needs of different fields for material properties.
What is the synthesis method of Isopropyl 2-Bromo-2-Methylpropanoate?
The synthesis of isopropyl 2-bromo-2-methylpropionate is a key issue in the field of organic synthesis. The synthesis method can follow the classical organic reaction path.
The first method of combining esterification with halogenation is to take 2-methylpropionic acid and make it esterify with isopropanol in the presence of a catalyst. Commonly used catalysts, such as sulfuric acid, p-toluenesulfonic acid, etc. This reaction needs to be carried out at an appropriate temperature and reaction time to promote its movement in the direction of forming isopropyl 2-methylpropionate.
After obtaining isopropyl 2-methylpropionate, it is then reacted with a brominating agent to introduce bromine atoms. Commonly used brominating agents, such as N-bromosuccinimide (NBS), bromine, etc. Under suitable reaction conditions, such as light and the presence of an initiator, the specific position of isopropyl 2-methylpropionate can be brominated to obtain isopropyl 2-bromo-2-methylpropionate.
There is also a method of reacting 2-bromo-2-methylpropionyl halide with isopropyl alcohol. First, the corresponding acyl halide is prepared from 2-bromo-2-methylpropionic acid. The commonly used halogenating reagents are thionyl chloride, phosphorus trichloride, etc. Then the acyl halide reacts with isopropanol in the presence of a base, which can neutralize the generated hydrogen halide and promote the reaction to obtain the final product.
During the synthesis process, attention should be paid to the precise control of reaction conditions, such as temperature, ratio of reactants, reaction time, etc., which have a great impact on the yield and purity of the product. And after each step of the reaction, it often needs to be separated and purified, such as distillation, extraction, column chromatography, etc., to obtain high-purity isopropyl 2-bromo-2-methylpropionate.
What are the precautions for Isopropyl 2-Bromo-2-Methylpropanoate in storage and transportation?
Isopropyl 2-bromo-2-methylpropionate is an organic compound. When storing and transporting, the following aspects should be paid attention to:
First, because of its flammability, it must be kept away from fire sources, heat sources and strong oxidants. If it encounters an open flame or hot topic, it is easy to cause combustion, or even explosion, which is extremely harmful.
Second, this compound is harmful to the human body. Contact with skin may cause irritation, inhalation or accidental ingestion can endanger health. Therefore, during storage and transportation, staff need to take protective measures, such as wearing appropriate protective gloves, protective glasses and gas masks, to avoid direct contact.
Third, it should be stored in a cool and well-ventilated place. High temperature environment will speed up its volatilization rate, enhance its chemical activity, and increase the risk. At the same time, good ventilation can prevent the accumulation of steam and reduce the risk of explosion.
Fourth, the storage container must be tightly sealed to prevent leakage. Once leaked, it will not only cause material loss, but also cause pollution to the environment. In case of open flames, it will add safety hazards. During transportation, it is also necessary to ensure that the container is stable to avoid collision and leakage.
Fifth, it should be stored and transported separately from acids, alkalis and other substances. Because it may chemically react with acids and bases, resulting in changes in properties and dangerous products.
In conclusion, the storage and transportation of isopropyl 2-bromo-2-methylpropionate requires strict compliance with relevant safety regulations and operating procedures, and careful treatment to ensure the safety of personnel and the environment.
What are the effects of Isopropyl 2-Bromo-2-Methylpropanoate on the environment and human health?
Isopropyl 2-bromo-2-methylpropionate is also an organic compound. In the environment, it may have many effects. If this substance is released in nature or is difficult to degrade, it accumulates in environmental media such as soil and water. In this way, it may disturb the structure and function of soil microbial communities, cause imbalances in soil ecosystems, and affect plant growth and development. In water bodies, it may harm aquatic organisms, interfere with their normal physiological functions, and even cause their death, disrupting the aquatic ecological balance.
As for human health, its impact cannot be ignored. It can enter the human body through inhalation, skin contact, or ingestion. In the body, or interfere with normal physiological and biochemical processes. For example, it may affect the function of the nervous system, causing headache, dizziness, fatigue and other symptoms. Long-term exposure may damage important organs such as the liver and kidneys, affecting their normal metabolism and detoxification functions. It may also have potential carcinogenic, teratogenic and mutagenic risks, threatening human reproduction and the health of future generations.
Therefore, the production, use and disposal of isopropyl 2-bromo-2-methylpropionate must be treated with caution to prevent it from causing serious consequences to the environment and human health.