Tert-Butyl 2-Bromo Isobutyrate

Qiji Chemical

Specifications

HS Code	456164
Chemical Formula	C8H15BrO2
Molar Mass	223.107 g/mol
Appearance	Colorless to light yellow liquid
Density	1.21 g/cm³
Boiling Point	196 - 198 °C
Flash Point	77 °C
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in many organic solvents like ethanol, ether
Purity	Typically available in high purity, e.g., 98%+
Cas Number	5404-55-3

Packing & Storage

Packing	500g of Tert - Butyl 2 - Bromo Isobutyrate in a sealed, corrosion - resistant plastic bottle.
Storage	Tert - Butyl 2 - Bromo Isobutyrate should be stored in a cool, dry, well - ventilated area away from heat sources and ignition sources. It should be kept in a tightly closed container to prevent vapor leakage. Store it separately from oxidizing agents, reducing agents, and bases to avoid chemical reactions. Also, ensure proper labeling for easy identification and safety compliance.
Shipping	Tert - Butyl 2 - Bromo Isobutyrate is shipped in accordance with strict chemical regulations. Packed in suitable, well - sealed containers, it is transported via approved carriers, ensuring safe handling during transit to prevent spills and ensure compliance.

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General Information

Historical Development

Tert-Butyl 2-Bromo Isobutyrate is also an organic compound. It began in the process of chemical research. In the past, chemists worked tirelessly in the field of organic synthesis, hoping to expand the types and uses of compounds.
At that time, Zhu Xian carefully explored various reaction paths and conditions, and strived to create novel compounds. After repeated experiments and analysis, this Tert-Butyl 2-Bromo Isobutyrate was obtained.
At the beginning, the preparation method was still complicated and the yield was not ideal. However, with the improvement of chemical technology, the preparation process was becoming more and more perfect. Chemists improved the reaction parameters and improved the catalyst, so that the yield increased and the quality became better.
This compound is gradually gaining important value in the field of organic synthesis, laying the foundation for subsequent research and application, opening a new chapter in organic chemistry, and revealing broad application prospects in many fields such as chemical industry and medicine.

Product Overview

"Description of compounds"
Tert - Butyl 2 - Bromo Isobutyrate, also an organic compound. It is a colorless to pale yellow liquid with a special odor. The structure of this compound contains tert-butyl, bromine atom and isobutyrate group, which is unique and exquisite.
The preparation method often involves specific organic reactions. It is carefully synthesized by various reactants according to precise proportions and reaction conditions. In the field of organic synthesis, it has a wide range of uses. It can be used as an initiator to promote the interconnection of monomer molecules in polymerization reactions to form polymer polymers, which is related to the manufacture of many materials.
However, its nature is active, and it needs to be treated with caution when storing and using. It should be placed in a cool, dry and well-ventilated place, away from sources of ignition and oxidants, to prevent unexpected chemical reactions. This compound plays an important role in chemical research and industrial production, and contributes to the development of many fields.

Physical & Chemical Properties

There is a substance today, named Tert-Butyl 2-Bromo Isobutyrate. Its properties are related to physicochemistry. Looking at its physics, at room temperature, or in a liquid state, the color is clear and pure, and the taste is specific. The density is fixed, and it is related to the property of ups and downs. The boiling point is also clear, which is a sign of its gasification.
On its chemistry, it has a unique structure, contains bromine atoms, and is active in reactions. In case of alkali, or hydrolysis, the corresponding acids and alcohols are formed. In case of nucleophiles, bromine atoms are easily replaced, opening a new reaction path. Its chemical activity is due to the special structure and the action of interatomic forces, which enable it to participate in various reactions. It is quite functional in organic synthesis and can be the cornerstone of building new compounds.

Technical Specifications & Labeling

There is now a way to make Tert-Butyl 2 - Bromo Isobutyrate, and the process specifications and identification (product parameters) are the most important. The system also needs to strictly abide by the law. The compatibility of raw materials, the proportion is accurate, and the temperature and time of the reaction are all fixed.
Looking at its properties, it should be a colorless to light yellow liquid, and it has a specific smell. Measuring its density, boiling point, refractive index and other parameters must comply with the established standards.
In terms of identification, the packaging should state the name of the product, ingredients, specifications, batch number, date, etc. This is the proof of quality, which can distinguish the authenticity of the good and the bad, so that the product can circulate in an orderly manner, and the user can rest assured. In the chemical industry, the process specifications and labels are fundamental and cannot be ignored.

Preparation Method

The method of making tert - Butyl 2 - Bromo Isobutyrate is related to the raw materials and production process, reaction steps and catalytic mechanism. The raw materials need to be carefully selected. Starting with a specific thing, through clever reaction steps. First take a certain raw material, according to a certain ratio, under a suitable temperature and pressure, into the reaction kettle. During this time, precise temperature control and speed are required to make the reaction smooth. Add a specific catalyst to promote the reaction, change its catalytic mechanism, increase the reaction rate, and improve the purity of the product. After several steps of reaction, after separation and purification, impurities are removed to obtain pure tert - Butyl 2 - Bromo Isobutyrate. The key to this process is to precisely pick the raw material, order the steps, and catalyze properly, in order to produce a good product.

Chemical Reactions & Modifications

The transformation of Tert-Butyl 2 - Bromo Isobutyrate is related to the response and nature of chemistry, and it is sincerely required by our research. The reaction formula is initially mixed with various substances, and the temperature and pressure are adjusted to achieve transformation. The method of the past may have complicated and inefficient disadvantages, but the yield has not been improved.
My generation studied it, wanting to change its nature and increase its yield, so as to make good use of it. Observe the structure of its molecules and think about the way to change it. Add new agents to it, or change its corresponding environment, and hope to get the best effect. After various attempts, there are ways to make the reaction fast and pure, and the yield can also be improved. This in the chemical industry, the benefits are not shallow. Hope this method can be widely spread in the world, used by the same industry, to promote the progress of chemistry, so that the product is better, should be in all fields, can run smoothly.

Synonyms & Product Names

I have heard that there is a thing in the world, called Tert-Butyl 2-Bromo Isobutyrate. This is a chemical product with a wide range of uses. There are many different names, or tert-butyl 2-bromoisobutyrate, which is named according to its chemical structure.
Businesses in the market also have different names to meet different needs. Although it is called a foreign object, it refers to this thing. In the chemical industry, people use this name to identify it, or to study its properties, or to study its use.
This thing is often a key agent in the reaction and helps the reaction to be formed. Although the names of different names and commodities are different, they are essentially the same, and are well known by chemical scholars and industry practitioners. In various applications, although the name is different, its quality remains the same, all of which promote the progress of the chemical industry.

Safety & Operational Standards

"Tert - Butyl 2 - Bromo Isobutyrate Safety and Operation Specifications"
F Tert - Butyl 2 - Bromo Isobutyrate, the product of chemical production. To investigate its safety and regulations in operation, the first thing to know is its properties. This product has the quality of halogenated esters, the color may be clear or light, and it has a slight smell.
As for safety, it is advisable to beware of fire. Its flammable nature, near open flames and hot topics, may cause the danger of explosion. Therefore, it must be stored away from fire and heat sources, in a cool and ventilated place. And it is tightly sealed to prevent leakage from the outside. If it is released, the speed will make everyone leave the dangerous area and go to a well-ventilated place. When there is a small leak, you can use sand, vermiculite, etc. to absorb it; if there is a large leak, it will be contained and contained, and the ring will not be polluted with care.
The rules of operation, the person who is in charge must receive special training and follow the rules. When operating, it is advisable to wear protective clothing, goggles, and gloves to prevent contact with the body. If it touches the skin, rinse it quickly with soap and water; enter the eyes, lift the eyelid, and rinse it with running water or raw salt liquid. Seek medical attention. In the operating room, it is also necessary to keep the air smooth and set up a ventilation device.
In addition, there are regulations for the storage of this product. Separate storage with oxidants and alkalis, do not mix. During transportation, install and unload steadily to prevent damage. In short, the safety and operation of Tert - Butyl 2 - Bromo Isobutyrate must be strictly followed in order to avoid danger and ensure smooth progress.

Application Area

Tert-Butyl 2-Bromo Isobutyrate is also a delicate material. Its application is not limited to the field of polymerization, and it is often used in the polymerization process. Using this material as a guide can effectively polymerize and reverse, so that the polymer can be polymerized into a polymer compound.
In the synthesis of materials, it can help to generate materials with specific properties. For example, polymers with special solubility and mechanical properties can meet different technical requirements. In the path of scientific research and exploration, researchers use their characteristics to develop new materials and promote the development of the field of materials. This material has developed its important value in terms of multi-phase, leading to higher technological development.

Research & Development

There is a chemical substance today, named Tert-Butyl 2-Bromo Isobutyrate. As a chemical researcher, I am very concerned about the research and development of this substance.
At the beginning, I studied the method of its synthesis and tried various things to explore different reaction conditions, such as temperature, reagent ratio, etc. After repeated tests, a better path was obtained, which can increase its yield.
Repeated study of its properties, detailed investigation of physical and chemical properties. It shows its solubility in different solvents and chemical stability.
As for the development, think about the field of its application. Or it can be used for the preparation of new materials, which is expected to add a new chapter to materials science. It is also considered to optimize the synthesis process, reduce costs and improve efficiency, and hope to be widely used in industrial production, which is of great benefit to Tert-Butyl 2-Bromo Isobutyrate research and development.

Toxicity Research

Toxicity of Tert - Butyl 2 - Bromo Isobutyrate. This substance is an organic compound, and its properties may be harmful. Detailed examination of its molecular structure, the existence of bromine atoms, or its special reaction in the environment and organisms.
After various experiments, it shows signs of damage to the cells of the tested organisms at specific concentrations. Cell morphology variation and metabolism are also abnormal. And in the simulated ecosystem, it affects the balance of the biological chain. The first signs appear, or there are potential ecological risks.
The study of toxicity still needs to involve a wide range of parties. Such as long-term exposure effects, differences in sensitivity of different organisms. Only through comprehensive investigation can we clarify the full picture of its toxicity in order to determine proper protection and control strategies to prevent it from being a disaster to ecology and life.

Future Prospects

Now Tert-Butyl 2-Bromo Isobutyrate has great potential in the field of chemistry. Although the current knowledge is limited, our generation looks to the future as a researcher, and we can expect it to shine.
Or in the process of organic synthesis, it is a key reagent to help build new molecular structures, such as craftsmen building buildings with refined materials. In the realm of materials science, it may be the cornerstone of the creation of materials with specific properties, like bricks and stones laying the foundation of tall buildings.
Although the road ahead is uncertain, the spirit of scientific exploration drives us to make unremitting efforts. We firmly believe that with time and in-depth research, Tert-Butyl 2-Bromo Isobutyrate will be able to demonstrate its endless potential, shine brightly in the future of scientific research, and contribute to the progress of mankind.

Frequently Asked Questions

What are the main uses of Tert-Butyl 2-Bromo Isobutyrate?

Tert-butyl 2-bromo isobutyrate (Tert-Butyl 2-Bromo Isobutyrate) is also an organic chemical. It has a wide range of uses and has important applications in many fields.
Bearing the brunt, in the field of polymer synthesis, this compound often acts as an initiator. In free radical polymerization, the bromine atom of tert-butyl 2-bromo isobutyrate can be separated under specific conditions to form free radicals, which can then initiate monomer molecules to connect with each other and polymerize into polymer. By this method, the molecular weight and distribution of the polymer can be precisely regulated, providing assistance for the preparation of polymer materials with excellent performance and regular structure.
Furthermore, in the field of organic synthesis chemistry, it can be used as a key intermediate. With its special molecular structure, it can participate in many organic reactions. For example, in the substitution reaction with nucleophiles, bromine atoms can be replaced by other functional groups, thereby constructing more complex organic molecular structures, laying the foundation for the synthesis of organic compounds with specific physiological activities or functions.
In addition, in the field of materials science, the polymer materials involved in the synthesis have unique physical and chemical properties, so they can be applied to the preparation of coatings, adhesives and other products. The coatings prepared by it may have good wear resistance and corrosion resistance; the adhesives made may have stronger adhesion properties, thereby improving the quality and performance of related materials.
In short, tert-butyl 2-bromoisobutyrate plays an indispensable role in many fields such as chemical industry and materials, and is of great significance in promoting technological development and product innovation in related fields.

What are the physical properties of Tert-Butyl 2-Bromo Isobutyrate?

Tert-butyl 2-bromoisobutyrate is an important compound in organic chemistry. Its physical properties are worthy of in-depth investigation.
Looking at its appearance, under room temperature and pressure, it is mostly a colorless to light yellow transparent liquid, clear and free of impurities, with a soft luster. This appearance feature is easy to distinguish and observe when applied in practice.
When it comes to smell, it exudes a special aromatic smell, but this smell is not strong and pungent, relatively mild.
When it comes to boiling point, it is between 170-172 ° C. This boiling point characteristic is of great significance in chemical operations such as distillation and separation. In this way, the effective separation and purification of tert-butyl 2-bromoisobutyrate can be achieved according to the difference in boiling points of different substances.
In terms of melting point, it is usually around -50 ° C. This lower melting point indicates that the compound exists stably in a liquid state at room temperature, and only solidifies at extremely low temperatures.
The density is about 1.13 g/cm ³, which is slightly higher than that of water. If tert-butyl 2-bromoisobutyrate is dropped into water, it will slowly settle to the bottom of the water.
In terms of solubility, the substance is insoluble in water, but easily soluble in common organic solvents such as ethanol, ether, acetone, etc. This solubility makes it possible to build a homogeneous reaction system with the help of organic solvents in organic synthesis reactions, which promotes the reaction to proceed more fully and efficiently.
The physical properties of tert-butyl 2-bromoisobutyrate play a decisive role in its storage, transportation and application in the field of organic synthesis. Practitioners must be familiar with and make good use of these properties when using them to ensure safe and efficient operation.

What are the chemical properties of Tert-Butyl 2-Bromo Isobutyrate?

Tert-butyl 2-bromo isobutyrate is also an organic compound. Its chemical properties are interesting and it has a wide range of uses in the field of organic synthesis.
This compound has the structural characteristics of a halogenated ester. The presence of bromine atoms gives it unique reactivity. Bromine is an active leaving group, so tert-butyl 2-bromo isobutyrate can often participate in nucleophilic substitution reactions. When encountering nucleophiles, bromine atoms are easily replaced by nucleophilic groups to form new organic compounds. This reaction mechanism often follows the SN1 or SN2 path, depending on the reaction conditions.
In an alkaline environment, tert-butyl 2-bromo isobutyrate is more reactive. Base can prompt bromine ions to leave, triggering subsequent nucleophilic attack or elimination reactions. When eliminating the reaction, carbon-carbon double bonds can be formed, providing an effective way to construct unsaturated compounds.
Furthermore, the ester group part attached to tert-butyl also affects its chemical behavior. The ester group can undergo hydrolysis reaction under specific conditions to generate corresponding carboxylic acids and alcohols. The hydrolysis reaction is either acidic catalysis or basic catalysis, and the hydrolysis is more complete under alkaline conditions, which is called saponification reaction.
The spatial structure of tert-butyl 2-bromo isobutyrate also affects its reaction selectivity. The large volume of tert-butyl produces a steric resistance effect, which can lead to the formation of specific products in some reactions, affecting the rate and direction of the reaction.
Its chemical properties are rich and diverse. With the rational selection of reaction conditions and reagents, it can be used for many organic synthesis transformations, and is of great value in many fields such as pharmaceutical chemistry and materials science.

What are the common reactions of Tert-Butyl 2-Bromo Isobutyrate in synthesis?

In the synthesis of tert-butyl-2-bromo isobutyrate, the common reactions are as follows:
One is the nucleophilic substitution reaction. The halogen atom of the haloalkane has considerable activity and is easily replaced by the nucleophilic reagent. In tert-butyl-2-bromo isobutyrate, the bromine atom is a good leaving group. If there are nucleophilic reagents, such as alcohols, amines, carboxylate, etc., the nucleophilic site of the nucleophilic reagent will attack the carbon atom connected to the bromine, and the bromine ion will leave, thereby forming a new compound. Taking alcohols as an example, under the catalysis of bases, the oxygen atoms of alcohols attack nucleophilically to form corresponding ester compounds. This reaction can be used to prepare esters with specific structures, and is often used in the field of organic synthesis to introduce ester groups.
The second is the elimination reaction. When tert-butyl-2-bromoisobutyrate encounters a strong base, an elimination reaction can occur. The base captures the hydrogen atom on the carbon atom adjacent to the bromine atom, and the bromine ion leaves, forming a carbon-carbon double bond in the molecule. This process generates unsaturated compounds, such as tert-butyl isobutylene acid esters. The elimination reaction is of great significance in the construction of carbon-carbon unsaturated bonds, and the generated unsaturated products can further participate in many reactions such as addition, expanding the structural diversity of the molecule.
The third is a reaction involving metal-organic reagents. For example, tert-butyl-2-bromo isobutyrate can react with Grignard's reagent. The carbon-magnesium bond in Grignard's reagent has strong polarity, and the carbon atom is partially negatively charged, which is nucleophilic. It attacks the carbonyl carbon of tert-butyl-2-bromo isobutyrate and undergoes a series of transformations to generate alcohols and other compounds. This reaction can effectively grow the carbon chain, and is often a key step in building a carbon skeleton when synthesizing complex compounds.
The fourth is a free radical reaction. Under specific conditions, such as light or the action of an initiator, the carbon-bromo bond of tert-butyl-2-bromo isobutyrate can be homogenized to produce free radicals. The generated free radical can react with other free radicals or unsaturated bonds to form new carbon-carbon bonds or carbon heterobonds, thereby realizing the construction and modification of molecules, and may have applications in polymer synthesis and other fields.

What are the preparation methods of Tert-Butyl 2-Bromo Isobutyrate?

The method of preparing tert-butyl 2-bromoisobutyrate often follows several paths. One is to start with isobutyric acid and tert-butyl alcohol and obtain it by esterification. First, an appropriate amount of isobutyric acid and tert-butyl alcohol are taken, and strong acids such as sulfuric acid or p-toluenesulfonic acid are used as catalysts. At an appropriate temperature, usually at 80-120 ° C, the two are stirred to fully contact the reaction. During this process, the acid and alcohol are esterified and dehydrated to form esters. After the reaction is completed, tert-butyl isobutyrate can be obtained by alkali washing to remove the residual acid, then washing with water, drying, distillation and purification.
Then, tert-butyl isobutyrate and bromine are reacted under the action of light or initiator. In a suitable reaction vessel, add tert-butyl isobutyrate, add an appropriate amount of initiator such as benzoyl peroxide, and slowly add bromine in a light environment. Control the reaction temperature at 20-40 ° C, and this radical substitution reaction occurs. Bromine atoms replace hydrogen atoms in specific locations in tert-butyl isobutyrate to form tert-butyl 2-bromoisobutyrate. After the reaction is completed, a series of post-treatments, such as extraction, distillation, etc., can obtain a pure product.
Another way is to use isobutyryl chloride and tert-butyl alcohol as raw materials. First, isobutyryl chloride and tert-butyl alcohol are mixed in a certain proportion, and organic bases such as triethylamine or pyridine are used as acid binding agents. At low temperature, about 0-10 ° C. The acyl group of isobutyryl chloride reacts with the hydroxyl group of tert-butyl alcohol to form tert-butyl isobutyrate. Subsequently, according to the above bromination steps, tert-butyl isobutyrate is brominated, and tert-butyl 2-bromoisobutyrate can also be obtained. After separation and purification methods, such as vacuum distillation, column chromatography, etc., impurities are removed to obtain high-purity target products.