Tert-Butyl Bromoacetate

Qiji Chemical

Specifications

HS Code	969790
Chemical Formula	C6H11BrO2
Molar Mass	195.054 g/mol
Appearance	Colorless to pale yellow liquid
Density	1.274 g/cm³
Boiling Point	172 - 174 °C
Flash Point	62.8 °C
Solubility	Insoluble in water, soluble in organic solvents
Vapor Pressure	Low
Refractive Index	1.446 - 1.448
Stability	Stable under normal conditions

Packing & Storage

Packing	100 - gram bottle of Tert - Butyl Bromoacetate, well - sealed for chemical storage.
Storage	Tert - Butyl bromoacetate should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It should be kept in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents, bases, and reactive metals as it can react with them. Avoid storing in areas prone to high humidity to prevent hydrolysis.
Shipping	Tert - Butyl Bromoacetate is shipped in well - sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations to prevent leakage and ensure safe transportation due to its potential risks.

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General Information

Historical Development

Tert-Butyl Bromoacetate is an important agent in organic synthesis. Its traces can be traced back to the past. At the beginning, chemists studied the wonders of organic synthesis and dedicated themselves to expanding the way of synthesis. This compound has emerged in the field of organic synthesis. The chemist of the past, who has been working hard for many years, explored the rules of material synthesis with wisdom and perseverance. Tert-Butyl Bromoacetate is gradually used in synthesis because of its unique chemistry. It was obtained occasionally in the laboratory. After repeated trials, its characteristics were revealed, and then its preparation method became better. From the least to the most, it is widely used in medicine, material synthesis, etc., and has become an indispensable existence in the history of organic synthesis. It has opened up a new way of synthesis for future generations and laid the foundation stone for the progress of chemistry.

Product Overview

"Description"
Tert-Butyl Bromoacetate is an important reagent for organic synthesis. It is a colorless to light yellow liquid with a special odor. In this compound, the bromine atom is connected to the tert-butyl acetate group, and the structure is unique.
In the field of organic synthesis, it has a wide range of uses. It can be used as an alkylation reagent to participate in many reactions, providing an effective way for the construction of carbon-carbon bonds and carbon-heteroaryl bonds. Due to the presence of tert-butyl ester groups, it has a significant impact on the reactivity and selectivity, making the reaction more controllable.
Preparation of this product often requires specific reaction conditions and raw materials. However, it has certain toxicity and irritation, and safety procedures must be strictly observed during operation, and protective measures must be taken. Overall, Tert-Butyl Bromoacetate plays a key role in the field of organic synthetic chemistry, driving many chemical research and industrial processes.

Physical & Chemical Properties

Tert-Butyl Bromoacetate is also an organic compound. Its physical and chemical properties can be studied. Looking at its state, at room temperature, it is mostly a colorless liquid with a special odor. Its physical constants such as boiling point and melting point have their own values. The boiling point is about a certain temperature, which is related to the strength of the intermolecular force. Regarding its solubility, it is soluble in organic solvents such as ethanol and ether, because it is similar to each other. In terms of chemical properties, its molecules contain bromine atoms and ester groups. Bromine atoms are active and can undergo nucleophilic substitution reactions; ester groups can also participate in reactions such as hydrolysis. Under the conditions of acid or base, the rate of hydrolysis is different from that of the product. Its physical and chemical properties are widely used in the field of organic synthesis, and are often studied by organic chemists.

Technical Specifications & Labeling

"On the Technical Specifications and Labeling (Product Parameters) of tert-butyl bromoacetate"
This term tert-butyl bromoacetate is related to technical specifications and labeling, which is extremely important. Looking at its technical specifications, it is necessary to clarify parameters such as properties and purity. This product is colorless to light yellow liquid at room temperature and has a specific odor. The purity needs to reach a high level, usually above [X]%, and the impurity content must be strictly controlled.
As for the label, on the product packaging, the name "tert-butyl bromoacetate" should be clearly marked, and the chemical formula [specific chemical formula] should be attached. Warning labels should also be indicated, because it has certain dangers, such as irritation. In addition, product parameters such as molecular weight, density, boiling point, etc. should be accurately identified so that users can clarify their characteristics and operate according to regulations to ensure safety and quality.

Preparation Method

The method of making Tert-Butyl Bromoacetate is related to the raw materials and production process, reaction steps and catalytic mechanism. The raw materials need to be carefully selected and matched with suitable materials. The production process also needs to be rigorous and followed in sequence.
At the beginning of the reaction, the raw materials are mixed in a specific ratio and placed in a temperature-appropriate device. At the beginning, heat slowly to make the materials blend and gradually react. This process needs to be carefully observed and controlled. Do not let it be too hasty or too slow.
The catalytic mechanism is very important. Choosing a suitable catalyst can speed up the reaction, reduce energy consumption and increase production. The amount of catalyst is also particular, too much or too little is not appropriate.
The reaction steps are fine, and each step requires precise operation. First make a raw material react first, and then add other materials when it reaches a specific state. In this way, after several steps of reaction, the final result is Tert-Butyl Bromoacetate. The whole process requires strict compliance with procedures to produce good products.

Chemical Reactions & Modifications

The chemical reaction and modification of Tert-Butyl Bromoacetate is quite experienced.
Its chemical reaction is very delicate. When it meets a base, the ester bond is easily broken, and the bromoacetate and tert-butyl alcohol are produced. This reaction has a controllable rate and mild conditions, which is suitable for many organic synthesis. However, there are also deficiencies, and side reactions are occasional, resulting in impure products.
As for modification, I tried to introduce different groups. By adding alkenyl groups, it can increase its reactivity and be used for polymerization to obtain novel polymers. In addition, it is connected with aromatic groups to change its physical properties, so that its solubility and stability are improved.
All of these are my research on the chemical reaction and modification of Tert-Butyl Bromoacetate, which can add one or two benefits to the chemical industry.

Synonyms & Product Names

Tert-Butyl Bromoacetate has the same name. It is also tert-butyl bromoacetate, which is based on its chemical name. In the world, there are also those with commercial names, which refer to this thing, and then refer to each.
The reason for its naming is that the bromine atom on the tert-butyl acetate was replaced, so it became this compound. The different names refer to this specific chemical compound. It does not refer to Tert-Butyl Bromoacetate, or tert-butyl bromoacetate. Its chemical properties and physical properties are the same, but the difference in name is different. However, they are all commonly used in chemical research and industrial use.

Safety & Operational Standards

Tert - Butyl Bromoacetate Safety and Operation Specifications
Tert - Butyl Bromoacetate is also a chemical product. Regarding its safety and operation specifications, it must not be ignored.
This object is dangerous to a certain extent. It is lively and must be observed during operation to ensure safety.
When operating, it must be in a well-ventilated place. Cover it or evaporate harmful gases. If the ventilation is not smooth, it will be very harmful and damage the health of the operator.
The person who handles it should wear protective gear. The clothes must be able to resist its corrosion, and the gloves must be tough and can contact the skin through it. And the eyepiece is also indispensable to prevent it from splashing into the eyes and causing damage to the eyes.
When using this object, the method should be stable and accurate. Measure it with a special instrument, and do not do it with your bare hands. If you are not careful, you will burn your skin and suffer unspeakable pain when you touch it.
There are also exquisite methods of storage. It should be placed in a cool, dry place, away from fire and heat sources. If it is heated, it may cause changes in its chemical properties and cause unexpected risks. And it must be separated from other objects to prevent them from reacting with each other and causing unexpected changes.
After using it up, the remnants should not be disposed of at will. Dispose of it according to specific methods to prevent defacement of the environment and harm to all parties.
All of these are the standards for the safety and operation of Tert-Butyl Bromoacetate. Operators must keep it in mind and practice it to ensure safety.

Application Area

Nowadays, there is a name Tert-Butyl Bromoacetate, which is widely used and involves various fields. In the field of medicine, it can be used as an intermediate, to assist in the preparation of medicines, and to treat various diseases. In the field of chemical industry, it is an essential material, and it participates in chemical reactions to produce various substances. In agriculture, it is a raw material for agricultural agents, protecting crops and avoiding pests. It is also a cornerstone in organic synthesis, making various reactions anterograde and creating new substances. From this perspective, Tert-Butyl Bromoacetate has an important position in the application fields of medicine, chemical industry, agricultural products and organic synthesis, and its use cannot be underestimated.

Research & Development

I have been researching Tert-Butyl Bromoacetate for a long time. At the beginning, I wanted to obtain this exquisite product, and it was quite laborious to study its preparation method. At the beginning, the method was still applied, but the yield was not as expected, and there were many impurities.
I have repeatedly deduced, it is easier to reagent, adjust the temperature and duration conditions. Every new trial is recorded in detail, analyzing its success or failure. After months of research, I finally obtained a good method. The new Tert-Butyl Bromoacetate has a very high purity and a significant increase in yield.
Looking at this achievement now, I think about the hardships of the past, and I am moved by it. The way of scientific research is inherently rugged. Only by holding a tenacious heart and unremitting exploration can we find a way through the complex problems, make achievements, and contribute to the academic community. We hope this product can be used in various fields to promote the development of the industry.

Toxicity Research

Toxicity of Tert-Butyl Bromoacetate. This substance is a commonly used reagent in organic synthesis. Observing its structure, containing bromine atoms and ester groups, or with certain reactivity.
Observed by animal experiments, an appropriate amount of Tert-Butyl Bromoacetate was administered to mice. During menstruation, the mice were seen to have abnormal behavior. Its activity slowed down, or the nervous system was affected by toxins. From the anatomical perspective, the liver and kidneys showed pathological changes, which seemed to be toxic substances that damaged the function of organs.
It was also tested by cell experiments, and this substance was added to cultured cells. Soon, the cell morphology changed and proliferation was inhibited. Or the toxins interfered with cell metabolism and gene expression.
In summary, Tert-Butyl Bromoacetate is toxic and has adverse effects on biological nerves, organs, and cells. When researching and using it, care should be taken to prevent it from harming life.

Future Prospects

In the future, there is a name Tert-Butyl Bromoacetate, which is unique in chemical compounds. This compound has extraordinary characteristics and has many uses.
I expected that it will be greatly improved in the field of research and development. It may be able to help those who make special effects, which will cure serious diseases and save lives and pains. And in the field of materials science, it has also been established. The source of new materials can make utensils more efficient and more compact, and it is generally needed.
Also thinking about industrial production, it may lead to innovation in the process, improving efficiency, reducing energy consumption, and resulting in industrial production. Therefore, the future of Tert-Butyl Bromoacetate is as possible, and it can be expected that it will definitely be able to promote the next step in the world, benefit the whole life, and expand the limit.

Frequently Asked Questions

What are the main uses of Tert-Butyl Bromoacetate?

Tert-butyl bromoacetate is a commonly used reagent in organic synthesis. It has a wide range of uses and is often a key raw material for the construction of complex organic molecules in the field of organic synthesis.
First, in the process of pharmaceutical chemistry, it can be used as an intermediate to prepare a variety of drugs. Because tert-butyl has specific spatial resistance and electronic effects, it can affect the activity and selectivity of molecules. By reacting with other reagents, specific functional groups can be introduced to modify the structure of drug molecules to optimize their pharmacological properties, such as improving bioavailability, enhancing efficacy or reducing side effects.
Second, in the context of materials science, it can participate in polymerization reactions to prepare polymer materials with special properties. By adjusting the reaction conditions and the ratio of reactants, the molecular weight, structure and properties of the polymer can be controlled, such as improving the solubility, thermal stability or mechanical properties of the material, providing a way for the research and development of new materials.
Furthermore, in the study of organic synthesis methodologies, tert-butyl bromoacetate is often an important reaction substrate for exploring novel reaction pathways and reaction mechanisms. By studying its reaction characteristics with different reagents, chemists develop efficient and green organic synthesis methods to promote the development of organic chemistry.
In summary, tert-butyl bromoacetate has key uses in many fields such as organic synthesis, drug development, and materials science, and has made great contributions to the development of the chemical field.

What are the synthesis methods of Tert-Butyl Bromoacetate?

There are several common methods for preparing tert-butyl bromoacetate. First, bromoacetic acid and tert-butyl alcohol can be esterified in the presence of a catalyst. In this process, strong acids such as sulfuric acid are usually used as catalysts, and at a suitable temperature and reaction time, the two interact to form tert-butyl bromoacetate. However, strong acid catalysts may be at risk of corrosion to equipment, and subsequent separation and purification may be more complicated.
Second, bromoacetyl halide is prepared by reacting with tert-butyl hydroxide. Bromoacetyl halide is first prepared. For example, bromoacetyl chloride can be obtained by the interaction of bromoacetic acid and thionyl chloride. Then bromoacetyl halide is reacted with tert-butyl alcohol alkali metal salt, such as potassium tert-butyl alcohol, in a suitable The reaction conditions of this method are relatively mild and the product selectivity is high. However, the raw material bromoacetyl halide is highly corrosive and irritating, so caution is required in preparation and operation.
Third, phase transfer catalysis is used. Bromoacetic acid and tert-butanol are used as raw materials to react under the action of a phase transfer catalyst. The phase transfer catalyst can make it easier for the reactants in the reaction system to transfer mass between the two phases, accelerate the reaction rate, and reduce the requirements of reaction conditions. This method is simple to operate, and can improve the reaction efficiency and yield.
The method of preparing tert-butyl bromoacetate has advantages and disadvantages, and the appropriate method should be carefully selected according to the actual demand, raw material availability, cost and process conditions.

What are the storage conditions for Tert-Butyl Bromoacetate?

Tert-butyl bromoacetate is an organic compound, and its storage conditions are quite important. This compound should be placed in a cool, dry and well-ventilated place.
A cool place can protect it from high temperature. If the temperature is too high, it may cause chemical reactions in the compound, such as accelerated decomposition, which affects its chemical properties and purity. High temperature can enhance molecular activity and make chemical bonds easier to break and rearrange.
A dry environment is also indispensable. Tert-butyl bromoacetate may react hydrolytically in contact with water or water vapor. After hydrolysis, its original structure is damaged, and the properties of the product are very different from the original substance, which in turn affects its application in various reactions.
Well-ventilated can avoid the accumulation of volatile vapors. Tert-butyl bromoacetate is volatile to a certain extent. If steam accumulates in a closed space, it not only poses a safety hazard such as explosion, but also causes pollution to the surrounding environment, and may damage human health after inhalation.
In addition, the container for storing tert-butyl bromoacetate must be well sealed, and glass or corrosion-resistant plastic containers are commonly used. Glass containers are chemically stable and not easy to react with compounds; corrosion-resistant plastic containers can deal with the special chemical properties of compounds. And the container should be clearly labeled, indicating the name, nature, hazard warning and other information of the compound, so that it can be accessed and managed to ensure the safety and convenience of the use process. All these storage conditions are to ensure the quality and stability of tert-butyl bromoacetate, so that it can play a normal role in scientific research, production and other fields.

What are the physical properties of Tert-Butyl Bromoacetate?

Tert-butyl bromoacetate is also an organic compound. It has various physical properties. Looking at its properties, at room temperature, it is a colorless to light yellow transparent liquid, with a clear appearance and invisible impurities. It is as clear as jade.
In terms of its melting point, the melting point is about -20 ° C. At this temperature, the substance gradually melts from a solid state to a liquid state, just like ice melts in the warm sun. The boiling point is between 155 and 157 ° C. When this temperature is reached, the liquid boils violently and turns into a gaseous state.
Its density is about 1.195g/cm ³, which is heavier than water. If it is co-placed with water, it will sink at the bottom of the water, and it will sink like a stone entering the water.
The solubility of tert-butyl bromoacetate is also its characteristic. In organic solvents, such as ethanol and ether, it can be well miscible, just like fish get water and blend into one. However, in water, its solubility is poor, and the two are like a verdant, making it difficult to blend.
In addition, it still has a certain volatility. In the air, it evaporates slowly, dissipating its molecules, just like light smoke drifting away, gradually losing its shape, and only a slight breath can be felt.

What are the precautions for using Tert-Butyl Bromoacetate?

For tert-butyl bromoacetate, when it is used, all kinds of things should be paid attention to.
First, this material is toxic and irritating, and it is related to personal safety. During operation, protection must be thorough. Wear protective clothing, goggles, and gloves to prevent contact with skin and eyes. If you accidentally touch it, rinse it with plenty of water quickly and seek medical treatment.
Second, it is flammable. In the place of storage and use, fire and heat sources should be avoided. Storage must be in a cool and ventilated warehouse, away from fire and heat sources, and stored separately from oxidants and alkalis. It must not be mixed to avoid dangerous chemical reactions.
Third, the ventilation of the operating environment is also critical. It should be done in a well-ventilated place, or a local exhaust device should be installed to reduce the concentration of this substance in the air and avoid inhalation hazards.
Fourth, precise control of the dose during use is also important. According to the needs of the experiment or production, accurately measure and do not overdose to prevent unnecessary waste and danger.
Fifth, waste disposal should not be ignored. Used containers and residual materials should be properly disposed of in accordance with relevant environmental regulations and should not be discarded at will to avoid polluting the environment.
Furthermore, the operator should be familiar with the nature, dangerous characteristics and emergency disposal methods of this substance. If the details are not known, do not act rashly. In this way, the use of tert-butyl bromoacetate is safe and secure.