4-Bromochlorobenzene

Qiji Chemical

Specifications

HS Code	896415
Chemical Formula	C6H4BrCl
Molar Mass	191.45 g/mol
Appearance	Colorless to light - yellow liquid
Odor	Characteristic aromatic odor
Density	1.72 g/cm³ (at 20 °C)
Boiling Point	208 - 210 °C
Melting Point	-34 °C
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in ethanol, ether, benzene
Flash Point	88 °C
Refractive Index	1.586 (at 20 °C)

Packing & Storage

Packing	100 - gram bottle of 4 - Bromochlorobenzene, tightly sealed for chemical safety.
Storage	4 - Bromochlorobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from sources of ignition, heat, and incompatible substances like strong oxidizers. Store it in tightly sealed containers, preferably made of corrosion - resistant materials, to prevent leakage and contamination, ensuring safety during long - term storage.
Shipping	4 - Bromochlorobenzene is shipped in well - sealed, corrosion - resistant containers. It's handled with care due to its chemical nature. Shipments follow strict regulations to prevent spills and ensure safe transport.

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General Information

Historical Development

4 - Bromochlorobenzene, an organic compound. The origin of its history can be traced back to the dawn of chemistry. At that time, various sages studied organic chemistry and gradually explored such halogenated aromatics.
In the past, chemists dedicated themselves to the structure and properties of materials, and studied many halogenated benzenes. 4 - The discovery of Bromochlorobenzene was the result of chemists' exhaustive experiments and careful investigation of physical properties. At the beginning, it could only be made in a small amount by complicated methods, and was only used for research.
With the increasing progress of science, the method of preparation is getting better. Industry is gradually booming, and the demand for it is also increasing. People have improved the process to make its yield higher and widely used. From the treasures of the laboratory to the raw materials of industry, the history of 4-Bromochlorobenzene reflects the development of chemistry. Since the beginning of micro, it has gradually become a big view. It has its uses in organic synthesis, pharmaceutical preparation and other fields, promoting the rise of the industry and adding a splendid chapter to the history of chemistry.

Product Overview

4 - Bromochlorobenzene is an organic compound. It is a colorless to light yellow liquid with a special odor. The structure of this compound, above the benzene ring, has one bromine atom and one chlorine atom.
Its preparation method, or from a specific organic reaction. In the field of organic synthesis, 4 - Bromochlorobenzene has a wide range of uses. It can be used as an intermediate to prepare many drugs, pesticides and other fine chemicals.
In the reaction, its bromine and chlorine atoms are active and can participate in nucleophilic substitution and other reactions. According to different reaction conditions and reagents, other functional groups can be introduced to derive a variety of compounds. Its chemical properties are stable, but under suitable conditions, it can also exhibit unique reactivity. It is an important raw material for organic synthesis and has made great contributions to the development of the chemical industry.

Physical & Chemical Properties

4 - Bromochlorobenzene is an organic compound with unique physical and chemical properties, which is worth exploring by our generation.
In terms of its physical properties, this substance is mostly colorless to light yellow liquid at room temperature, with a special odor. Its boiling point is about 219 ° C, and its melting point is about -16 ° C. Such melting boiling point characteristics make its physical state easy to change under specific temperature conditions. The density is about 1.84g/cm ³, which is heavier than water and will sink to the bottom in water.
Looking at its chemical properties, 4 - Bromochlorobenzene has a certain chemical activity due to the presence of bromine and chlorine atoms on the benzene ring. The electron cloud density of the benzene ring is affected by the halogen atom, so that it can undergo electrophilic substitution reaction. Bromine and chlorine atoms can be replaced by other groups under suitable conditions, and then a variety of organic compounds can be derived, which are widely used in the field of organic synthesis. However, its chemical stability is also high, and it is not easy to decompose or react violently in general environments. Specific conditions are required to initiate chemical reactions.

Technical Specifications & Labeling

4 - Bromochlorobenzene, organic compounds are also. The process specification for its preparation, the purity of the first raw materials. The brominating agent and the chlorinating agent should be accurately measured and the ratio should be appropriate to obtain the best effect. The temperature of the reaction is also the key, and it should be controlled in a specific range to prevent side reactions from clumping.
The identification of the product (commodity parameters) is related to the quality. Its purity must be marked in detail, and the impurity content must be accurately measured and recorded. The color and state of the appearance should also be described in detail, or it is a colorless liquid or a white-like crystal.
When storing, it should be protected from light and cool, and away from the heat source of the kindle to prevent qualitative changes. When transporting, follow relevant regulations to ensure safety. In this way, the quality of 4-Bromochlorobenzene can be stabilized to meet the needs of various applications.

Preparation Method

4 - Bromochlorobenzene is an organic compound, and the preparation method is quite critical. In terms of raw material selection, chlorobenzene and brominating agents are commonly used. Brominating agents, such as liquid bromine with catalysts, are commonly used as iron filings or iron tribromide.
Preparation process is as follows: In the reaction vessel, first place chlorobenzene, and then slowly add liquid bromine and catalyst. This reaction needs to be carried out at a specific temperature, generally maintained at a moderate temperature to promote the smooth occurrence of the reaction. The reaction step is that the liquid bromine is first polarized under the action of the catalyst to form an active intermediate, and then an electrophilic substitution reaction occurs with chlorobenzene, and the bromine atom replaces the hydrogen atom on the benzene ring to generate 4 - Bromochlorobenzene
During this process, attention should be paid to controlling the reaction conditions. The temperature should not be too high, otherwise it will easily cause side reactions and generate polybrominates; nor should it be too low to prevent the reaction from being too slow. At the same time, the reaction time should also be precisely controlled to ensure the complete reaction. When the product is separated and purified, conventional methods such as distillation and extraction can be used to obtain high-purity 4-Bromochlorobenzene. In this way, the compound can be effectively prepared to meet experimental or production needs.

Chemical Reactions & Modifications

The current study of chemistry concerns the product of 4-Bromochlorobenzene. The reaction of chemistry is the key to scientific inquiry. The transformation of this product should be carefully observed by scholars.
At the beginning, the reaction follows the conventional way, but if you want better chemical properties, you must change. Or change the conditions of the reaction, such as the adjustment of temperature and pressure; or change the reagents used to find suitable agents.
After various attempts, observe the change. Or the purity of the product increases, or the rate of the reaction increases. This is a sign of improved chemical properties.
On the path of transformation, we continue to explore the wonders of reaction and transformation, such as the ancient sages seeking the way, unremitting, and reaching the realm of goodness, so that 4-Bromochlorobenzene products can be used in the field of transformation to develop unique capabilities and pave the way for various applications.

Synonyms & Product Names

4 - Bromochlorobenzene, a synonym for this thing and a trade name, is really worth studying. The name of the chemical substance, either according to its structure or according to its characteristics. 4 - Bromochlorobenzene, named after its molecular structure contains bromo (bromo -) and chloro (chloro -) atoms and is in a specific position in the benzene ring.
Its synonym, or derived from similar naming rules. When chemists name names, they often have different names due to different perspectives. Or emphasize the precedent of bromine, or the position of heavy chlorine, resulting in different expressions. As for the trade name, merchants promote it, or take an easy-to-remember name, or attach a unique meaning, hoping to stand out in the market.
Although its chemical essence is unique, the complexity of synonyms and trade names also reflects the diversity of appellation habits in the field of chemistry. When researchers communicate and consult literature, they must observe to avoid confusion and ensure that the information is accurate. This is all about the accuracy of chemical research and application.

Safety & Operational Standards

4 - Bromochlorobenzene is an organic compound, which is crucial to the safety and operation of this substance.
In terms of safety, 4 - Bromochlorobenzene is toxic. If its vapor or mist droplets are inhaled through the respiratory tract, it will cause damage to the human body, such as irritating the mucosa of the respiratory tract, causing symptoms such as cough and asthma. If accidentally exposed to the skin, it will cause skin allergies, redness, swelling, and itching. Once taken by mistake, it will endanger the digestive system and cause adverse reactions such as nausea, vomiting, and abdominal pain. Therefore, when operating 4 - Bromochlorobenzene, safety procedures must be strictly followed.
In terms of operating practices, first of all, the operating place should have good ventilation conditions to avoid the accumulation of its vapor. Operators need to wear professional protective equipment, such as protective gloves, protective glasses, gas masks, etc., to ensure that all parts of the body are protected from its damage. Secondly, when taking 4-Bromochlorobenzene, be sure to use clean and dry utensils to prevent impurities from mixing and affecting its quality. The weighing process should be accurate, and the dosage should be strictly controlled according to experimental or production needs. Furthermore, when storing 4-Bromochlorobenzene, it should be placed in a cool, dry and well-ventilated place, away from fire and heat sources. At the same time, it should be stored separately from oxidizers, acids and other substances to prevent dangerous chemical reactions. If 4-Bromochlorobenzene spills during operation, emergency measures should be taken immediately, such as covering with inert materials such as sand and vermiculite, then carefully collect and dispose of it properly, and must not be discarded at will to avoid polluting the environment. In short, only by strictly observing the safety and operation specifications of 4-Bromochlorobenzene can we ensure the safety of personnel and the smooth progress of experiments and production.

Application Area

4 - Bromochlorobenzene is also an organic compound. Its application field is quite wide. In the field of pharmaceutical synthesis, it is often an important intermediate. With its unique structure, it can participate in many reactions, help create new drugs, and contribute to the treatment of diseases.
In materials science, it also plays an important role. It can introduce polymer structures through specific reactions to improve the properties of materials, such as improving heat resistance and enhancing mechanical strength, so that the material is suitable for more severe scenarios.
Furthermore, in the field of pesticide research and development, 4 - Bromochlorobenzene can be used as a key raw material. After a series of chemical transformations, it can be made into highly efficient pesticides to control pests and diseases, ensure the harvest of crops, and make great contributions to agricultural production. It plays an important role in various application fields.

Research & Development

4 - Bromochlorobenzene is an organic compound. As a chemical researcher, we have conducted research and development on it.
The substitution of bromine and chlorine atoms in this compound determines its unique chemical properties. During the synthesis process, it is necessary to precisely control the reaction conditions to obtain high-purity products. In the past, the synthesis methods were more complicated and the yield was unsatisfactory.
However, with the evolution of chemical technology, new catalysts and reaction paths continue to emerge. Through unremitting research, we have found more efficient synthesis methods, which not only improve the yield, but also optimize the reaction selectivity.
At the application level, 4 - Bromochlorobenzene has emerged in the fields of medicine, materials and so on. In pharmaceutical research and development, it is a key intermediate to help create new drugs. In materials science, it can be used to prepare functional materials with special properties.
Our chemical researchers will continue to explore 4-Bromochlorobenzene in depth to explore its potential value, promote its wide application and development in various fields, and contribute to the progress of the chemical field.

Toxicity Research

Toxicity Study of 4 - Bromochlorobenzene
Recently, I have focused on the toxicity study of 4 - Bromochlorobenzene. This chemical is used more and more widely in the industrial field, but the effect of its toxicity on life is not yet clear.
I took a variety of experimental organisms and administered them at different doses of 4 - Bromochlorobenzene. Observe its physiological changes, abnormal behavior and organ damage. At first, no significant abnormalities were seen in the low-dose group, but with the increase of dose, the biological vitality gradually declined and the behavior was sluggish. It can be seen from the anatomy that the liver, kidneys and other organs are diseased and the cell structure is damaged.
From this, 4 - Bromochlorobenzene has a certain toxicity. In the future, we should explore its toxicological mechanism in depth to provide a solid basis for preventing its harm and ensuring the well-being of all beings.

Future Prospects

4 - Bromochlorobenzene, the future prospect of this substance, is related to the progress of our chemical research. Looking at the present, it has emerged in the field of organic synthesis, as a key intermediate, helping to create many complex compounds.
My generation looks to the future. First, we hope to make a breakthrough in the green synthesis path. Today's chemical trend is towards green and environmental protection. If the preparation of 4 - Bromochlorobenzene can find a more gentle, efficient and less polluting method, it will be a great progress. Second, expand its application boundaries. In addition to existing fields, it may be able to explore new potential in the research and development of new materials, such as optoelectronic materials, functional polymers, etc. This can not only promote the development of chemistry, but also hope to bring innovation to related industries.
Although the road ahead may be difficult, we chemical researchers, with the heart of exploration, should make unremitting efforts to lead 4-Bromochlorobenzene into a new journey and contribute to future scientific and technological progress.

Frequently Asked Questions

What is the chemistry of 4-Bromochlorobenzene?

4-Bromochlorobenzene is also an organic compound. In its molecular structure, bromine and chlorine atoms on the benzene ring occupy one place each. The chemical properties of this substance are quite unique, and there are many things to be said.
First of all, its substitution reaction. Due to the influence of bromine and chlorine atoms, the electron cloud density distribution of the benzene ring is different from that of benzene. Both are electron-absorbing groups, which can reduce the electron cloud density of the benzene ring, so the electrophilic substitution reaction is more difficult than that of benzene. However, the substitution positions can be followed regularly. Although both bromine and chlorine have electron-absorbing induction effects, their conjugation effects cannot be ignored. The positioning effects of the two are similar, and both are ortho and para-localization groups. Therefore, when electrophilic reagents attack If mixed with nitric acid and sulfuric acid, nitro substitutes can be formed, and the nitro group mostly falls in the adjacent and para-position of bromine and chlorine.
Then talk about its addition reaction. Although the benzene ring of 4-bromochlorobenzene is aromatic and difficult to add, it can also occur under certain conditions. If it is at high temperature, high pressure and there is a catalyst, it can be added with hydrogen, and the unsaturated bond of the benzene ring is gradually hydrosaturated to form a saturated cyclic compound containing bromine and chlorine.
The properties of its halogen atoms are also considerable. Bromine and chlorine atoms have certain activities. Under the action of appropriate nucleophiles, nucleophilic substitution reactions can occur. For example, with sodium alcohol, sodium phenol and other reagents, bromine or chlorine atoms can be replaced by alkoxy and phenoxy groups to form corresponding ether compounds.
In addition, 4-bromochlorobenzene is widely used in the field of organic synthesis. It is often used as a raw material. After various reactions, a variety of organic compounds can be prepared, which are used in drug synthesis, material preparation and many other aspects. The study of its chemical properties is of great significance to the development of organic chemistry and the progress of related industries.

What are the physical properties of 4-Bromochlorobenzene?

4-Bromochlorobenzene is also an organic compound. It has specific physical properties, which are described below.
Looking at its properties, under room temperature and pressure, 4-bromochlorobenzene is colorless to light yellow crystalline and stable in quality. Its melting point is quite considerable, between about 63 ° C and 65 ° C. Such melting point characteristics make it possible to achieve solid-liquid state change in similar temperature ranges.
As for the boiling point, the boiling point of 4-bromochlorobenzene is about 219 ° C. The higher boiling point indicates that more energy needs to be supplied to convert it from liquid to gas. This property is of great significance in chemical operations such as separation and purification.
The density of 4-bromochlorobenzene is also one of its important physical properties, about 1.84g/cm ³. Compared with common solvents such as water, the density is higher. This difference can cause 4-bromochlorobenzene to stratify with low-density liquids such as water in processes such as liquid-liquid separation, which is convenient for separation by means of liquid separation.
In terms of solubility, 4-bromochlorobenzene is insoluble in water. Water is a polar solvent, while the polarity of 4-bromochlorobenzene molecules is weak. According to the principle of "similar miscibility", its solubility in water is very small. However, it is soluble in many organic solvents, such as ethanol, ether, benzene, etc. In organic solvents such as ethanol, 4-bromochlorobenzene molecules can interact with organic solvent molecules through intermolecular forces to achieve dissolution. This solubility characteristic is often used to select suitable reaction media and separation solvents in organic synthesis and related reactions.
In addition, 4-bromochlorobenzene has a certain degree of volatility and will slowly dissipate into the air at room temperature. Although the volatility is not strong, during operation, it is still necessary to pay attention to safety measures such as ventilation to prevent it from accumulating in the air and causing potential hazards.

What are the main uses of 4-Bromochlorobenzene?

4-Bromochlorobenzene is also an organic compound. It has a wide range of uses and is used in all fields of chemical industry.
The first to bear the brunt. In the field of drug synthesis, 4-bromochlorobenzene is often an important raw material. Due to its special structure, specific functional groups can be introduced through various chemical reactions, and then complex drug molecular structures can be constructed. For example, when synthesizing some antibacterial and anti-inflammatory drugs, 4-bromochlorobenzene can be used as a starting material. After many reaction steps such as halogenation, substitution, and condensation, the required active pharmaceutical ingredients can be gradually prepared.
Furthermore, in the field of materials science, it also has a place. In the preparation of high-performance polymer materials, 4-bromochlorobenzene can participate in the polymerization reaction, giving the material special properties. For example, it can be used to synthesize engineering plastics with good thermal stability and mechanical properties, providing high-quality materials for aerospace, automotive manufacturing and other fields. Such materials can maintain stable properties under harsh environments such as high temperature and high pressure due to the participation of 4-bromochlorobenzene.
In addition, in the dye industry, 4-bromochlorobenzene also plays an important role. By chemically modifying it, dyes with bright colors and excellent fastness can be prepared. Its structure can firmly combine dye molecules with fibers and other substrates, ensuring that the dyeing effect is long-lasting and not easy to fade. It is widely used in textile printing and dyeing and other industries to add brilliant color to fabrics.
In summary, 4-bromochlorobenzene, with its unique chemical structure, has shown indispensable value in many fields such as drugs, materials, dyes, etc., promoting the development and progress of various industries.

What are 4-Bromochlorobenzene synthesis methods?

The synthesis of 4-bromochlorobenzene often involves several methods. First, benzene is used as the starting material and halogenated first. First, benzene and bromine are brominated with the help of catalysts such as iron bromide to obtain bromobenzene. In this reaction, the bromine atom selects the hydrogen on the benzene ring and substitutes it for aromatic hydrocarbons. Bromobenzene is obtained, and then it is combined with chlorine in an appropriate catalyst such as iron powder. After chlorination, 4-bromochlorobenzene can be obtained. This process requires careful control of the reaction conditions, such as temperature and the proportion of reactants, to increase the yield of the target product.
Second, chlorobenzene is used as the raw material to react with bromine in the presence of the catalyst. The commonly used catalysts are iron filings and their halides. In this electrophilic substitution reaction, the bromine atom selects the hydrogen substitution at a specific position on the chlorobenzene ring, and 4-bromochlorobenzene can be obtained because chlorine is an ortho-para-localization group. However, there will also be by-products of other substitutions in the reaction, so the reaction conditions must be adjusted properly, such as precise temperature control and moderate selection of the amount of catalyst, in order to reduce the degree of side reactions and improve the purity of the product.
Furthermore, phenolic compounds can be initiated. For example, phenol is first halogenated to obtain halogenated phenol, and then through diazotization and Sandmeier reaction, the synthesis of 4-bromochlorobenzene can be achieved. However, this approach has more steps, the process is slightly more complicated, and the control of operating skills and reaction conditions is higher, but in some specific scenarios, it may have unique advantages. In short, all synthesis methods have their own advantages and disadvantages. In practical application, when the availability of raw materials, cost, product purity and other factors, it should be carefully selected.

What are the precautions in storage and transportation of 4-Bromochlorobenzene?

4-Bromochlorobenzene is also an organic compound. During storage and transportation, many matters must be paid attention to.
First of all, store in a cool, dry and well-ventilated place. It is easy to cause chemical changes or be dangerous when covered by heat. The temperature of the warehouse should be controlled in an appropriate range to prevent the temperature from being too high and causing changes in material properties. And it should be kept away from fire and heat sources, both of which can cause reactions, leading to fire and explosion.
Furthermore, 4-bromochlorobenzene must be stored in parts with oxidants and food chemicals. Because of its active chemical properties, it can mix with other substances or react violently. The storage area should also be equipped with suitable materials to contain leaks, so as to prevent accidents and dispose of them in time to prevent their spread and environmental pollution.
As for transportation, it should not be neglected. Before transportation, ensure that the packaging is complete and sealed. The packaging material should be corrosion-resistant and can resist the erosion of 4-bromochlorobenzene. During transportation, the speed should be slow, and violent actions such as sudden braking and sharp turns should be avoided to prevent damage to the packaging and material leakage.
The escort personnel must also be familiar with its characteristics and emergency response methods. If there is a leak on the way, measures can be taken quickly according to the plan. The transportation vehicle should also be checked regularly to ensure that the vehicle is in good condition and has no potential safety hazards. In this way, the safe storage and transportation of 4-bromochlorobenzene can be ensured, and harm can be avoided.