4-Bromofluorobenzene

Qiji Chemical

Specifications

HS Code	607470
Chemical Formula	C6H4BrF
Molar Mass	175.00 g/mol
Appearance	Colorless to pale yellow liquid
Boiling Point	154 - 156 °C
Melting Point	-27 °C
Density	1.587 g/cm³
Flash Point	47 °C
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in many organic solvents like ethanol, ether
Odor	Characteristic aromatic odor
Refractive Index	1.544

Packing & Storage

Packing	500g of 4 - Bromofluorobenzene packaged in a sealed glass bottle.
Storage	4 - Bromofluorobenzene should be stored in a cool, well - ventilated area, away from heat sources and open flames to prevent ignition. It should be stored in a tightly - sealed container, preferably made of corrosion - resistant materials like stainless steel or glass, to avoid leakage and contact with air or moisture which could potentially cause decomposition or reaction. Keep it separate from oxidizing agents.
Shipping	4 - Bromofluorobenzene is shipped in tightly - sealed, corrosion - resistant containers. It's transported via approved carriers following strict hazardous chemical shipping regulations to ensure safety during transit.

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General Information

Historical Development

4 - Bromofluorobenzene is also an organic compound. Its historical evolution is worth exploring. In the past, organic chemistry was at the beginning of its rise, and all the wise men did their best in the analysis and synthesis of compounds.
At that time, the study of aromatic compounds became more and more prosperous, and 4 - Bromofluorobenzene also entered the field of vision of chemists. In the early days, due to technical limitations, it was difficult to synthesize this compound. However, chemists relied on their tenacity to experiment repeatedly and improve their methods.
With the passage of time, organic synthesis technology has become increasingly exquisite. New catalysts and optimization of reaction conditions have greatly improved the synthesis efficiency of 4 - Bromofluorobenzene. Today, this compound is widely used in medicine, materials and other fields. Looking at its historical development, it is a clear evidence of chemical progress and a cornerstone for future generations to explore the unknown.

Product Overview

4 - Bromofluorobenzene
4 - Bromofluorobenzene is a crucial compound in the field of organic synthesis. Its molecular structure is unique. On the benzene ring, bromine and fluorine atoms occupy specific positions, giving this compound specific chemical properties.
Looking at its physical properties, under room temperature and pressure, 4 - Bromofluorobenzene is often a colorless to slightly yellow liquid with a special odor. Its physical parameters such as boiling point and melting point are of great significance in the control of organic synthesis reaction conditions. Data such as the exact value of boiling point can help chemists precisely control the reaction temperature and ensure that the reaction is carried out in a suitable environment.
As for the chemical properties, 4-Bromofluorobenzene exhibits unique reactivity due to the electronegativity difference between the benzene ring conjugated system and bromine and fluorine atoms. The electron-absorbing effect of fluorine atoms and the exodus of bromine atoms make it easy to participate in various organic reactions such as nucleophilic substitution reactions. Chemists can use this compound to construct complex organic molecular structures by ingeniously designing reaction paths, which is widely used in drug synthesis, materials science and other fields.
4-Bromofluorobenzene has important application value in many fields, and its unique properties provide a solid foundation and infinite possibilities for the development of organic synthetic chemistry.

Physical & Chemical Properties

4 - Bromofluorobenzene is an organic compound, and its physical and chemical properties are particularly important. Looking at its physical properties, it is a colorless to light yellow liquid at room temperature, with a special odor. Its boiling point is between 150-155 ° C, its melting point is about -27 ° C, and its density is about 1.71 g/cm ³.
In terms of chemical properties, the activities of bromine and fluorine atoms in this compound are different. Due to the strong electronegativity of fluorine atoms, the density distribution of electron clouds in the benzene ring changes, which affects the electrophilic substitution reaction activity. Although bromine atoms also have certain activity, due to the existence of fluorine atoms, their reaction check points are different from those of ordinary bromobenzene. This compound has a wide range of uses in the field of organic synthesis. It can be used to prepare a variety of organic materials and pharmaceutical intermediates with special structures and functions through nucleophilic substitution, coupling reactions, etc. Its physical and chemical properties are explored, which is of great significance for expanding organic synthesis methods and developing new compounds.

Technical Specifications & Labeling

4 - Bromofluorobenzene is an important organic compound. It is necessary to elaborate on its technical specifications and labeling (product parameters).
As far as technical specifications are concerned, its purity must meet very high standards, and the impurity content must be strictly controlled at a very low level. The appearance should be colorless and transparent, and there should be no visible turbidity or foreign matter. Physical parameters such as melting point and boiling point also need to fit specific ranges to ensure stable quality.
In terms of labeling, the name "4 - Bromofluorobenzene" should be clearly marked on the product packaging, and a warning label should be attached to indicate its chemical properties and latent risks. Product parameters should also be listed in detail, such as purity values, impurity types and content, so that users can clarify product characteristics, apply them safely and accurately, and play their due role in chemical research and other fields.

Preparation Method

To prepare 4-Bromofluorobenzene, it is necessary to clarify its raw materials and production process, reaction steps and catalytic mechanism. Fluorobenzene and brominating agent are often selected as raw materials. First, fluorobenzene and brominating agent are reacted under specific conditions. In this case, catalyst assistance may be required to promote the efficient progress of the reaction.
The first step is to mix the raw materials, precisely control the proportion, and create a suitable reaction environment, such as temperature and pressure. Usually heated to increase molecular activity, so that the reaction is prone to occur. In the catalytic mechanism, the catalyst can reduce the activation energy of the reaction and accelerate the reaction rate.
In this reaction, or iron or iron salt is selected as the catalyst, which reacts with the brominating agent to produce an active intermediate, which is easier to react with fluorobenzene. After a series of reaction steps, the raw material is gradually converted into 4-Bromofluorobenzene. In this way, the desired product can be prepared according to the above method.

Chemical Reactions & Modifications

4-Bromofluorobenzene is also an organic compound. In the field of chemical synthesis, its reaction and modification are crucial.
In the past, to prepare 4-Bromofluorobenzene, a specific halogenation reaction was often used. However, this ancient method did not achieve ideal yield, and side reactions occurred frequently.
Today's chemists have worked hard to improve their reaction paths. With the addition of new catalysts, the reaction conditions are gradually milder and the yield is greatly improved. And by precisely regulating the reaction parameters, side reactions can be effectively suppressed.
In terms of its modification, chemists have ingeniously introduced various functional groups, endowed 4-Bromofluorobenzene with new properties, and expanded its application in materials science, drug development and other fields. This is the result of the unremitting exploration and refinement of chemical researchers.

Synonyms & Product Names

4 - Bromofluorobenzene is an organic compound. Its synonymous name, or p-bromofluorobenzene. It is sold in the market, and the trade name of this chemical is also called this.
In the field of Guanfu chemistry, there are many things, which is common. This 4 - Bromofluorobenzene, according to its chemical structure, is called by the system nomenclature, so it is called this. And p-bromofluorobenzene is called by the relative position and type of substituents on its benzene ring.
In the chemical industry, this compound is widely used. Because of its special chemical properties, it is often used as a raw material for the synthesis of other fine chemicals. Or used in pharmaceutical creation, or used in material research and development, all rely on its unique reactivity. Therefore, knowing its synonymous names and trade names is essential for practitioners to facilitate communication, research, and production.

Safety & Operational Standards

4 - Bromofluorobenzene is a compound commonly used in organic synthesis. In its experimental operation and production process, safety and operating standards are extremely important.
In terms of safety, 4 - Bromofluorobenzene has certain toxicity and irritation. Contact with its vapor or fog can cause eye and upper respiratory tract irritation. Skin contact can cause burns. Therefore, when operating, it must be carried out in a well-ventilated environment, preferably in a fume hood to avoid vapor accumulation. Operators must wear appropriate protective equipment, such as protective glasses, gas masks (if the vapor concentration is high), and chemically resistant gloves and work clothes to prevent skin and respiratory contact.
In terms of operating specifications, when using 4 - Bromofluorobenzene, clean and dry utensils should be used to avoid impurities from mixing. Measurement must be accurate, according to the amount required for experiment or production, to prevent waste. Due to its flammability, the operation site should be kept away from fire and heat sources, and smoking is strictly prohibited.
Store 4 - Bromofluorobenzene in a cool, dry and well-ventilated place, away from oxidants and fires. Storage containers must be well sealed to prevent leakage. In the event of a leak, personnel from the contaminated area of the leak should be quickly evacuated to a safe area and quarantined to strictly restrict access. Emergency responders must wear self-contained positive pressure breathing apparatus and anti-toxic clothing. Do not let leaks come into contact with combustible substances (such as wood, paper, oil, etc.). When a small amount leaks, it can be absorbed by sand, vermiculite or other inert materials, or it can be rinsed with a large amount of water, diluted with washing water, and placed in the wastewater system; when a large amount leaks, build a dike or dig a pit for containment, cover it with foam to reduce steam disasters, and transfer it to a tanker or a special collector with an explosion-proof pump for recycling or transportation to a waste treatment site for disposal.
Operation 4 - Bromofluorobenzene process, only by strictly observing safety and operating standards can we ensure the safety of personnel and the smooth progress of experiments and production.

Application Area

4 - Bromofluorobenzene, also organic compounds. Its application field is quite wide. In the field of medicinal chemistry, it can be used as a key intermediate to synthesize a variety of specific drugs, such as antibacterial and antiviral agents, to help human health. In the field of materials science, this can be used as a raw material to make materials with special properties, such as photoelectric materials, which show unique advantages in electronic display. In the field of pesticide chemistry, it can synthesize high-efficiency and low-toxicity pesticides to protect agricultural production and reduce pollution. And it is often used as an important substrate in organic synthesis reactions, providing a cornerstone for the construction of complex organic molecular structures, promoting the continuous progress of organic chemistry research, and is of great significance to the development of related industries.

Research & Development

4 - Bromofluorobenzene is an organic compound. Our generation explored its research and development process as a chemical researcher. In the past, the method of organic synthesis was still simple, and it was quite difficult to obtain this compound.
However, with the advancement of chemical technology, new synthesis paths have emerged. After repeated experiments, chemists have optimized the reaction conditions to improve the yield and purity of 4 - Bromofluorobenzene. The study of the reaction mechanism is also in-depth, and the chemical changes of each step are understood, laying the foundation for the improvement of the synthesis method.
Today, 4 - Bromofluorobenzene is increasingly used in medicine, materials and other fields. Its research and development path, from difficult to easy, from shallow to deep, has contributed to the development of the chemical field, and will surely bloom in more fields in the future, promoting the progress of related industries.

Toxicity Research

Today there is a chemical substance 4 - Bromofluorobenzene. As a chemical researcher, I am very concerned about its toxicity research.
The toxicity of this substance is related to the health of everyone and the safety of the environment, and cannot be ignored. I read the classics and experimented carefully to obtain the truth.
At first, white mice were tested and fed food containing this substance. Not long after, the white mice gradually showed a different state, their movements were slow, and their diet gradually decreased. Looking at it, there was a sign of damage to the organs.
It was also tested on plants. Sprinkling this substance on the soil, the growth of plants was blocked, and the leaves gradually turned yellow.
From this perspective, 4 - Bromofluorobenzene is toxic and harmful to the growth and development of organisms. I should record the results in detail, so that everyone can know the harm. During production and use, I should be careful not to spread the harm, so as to ensure the well-being of all things.

Future Prospects

4 - Bromofluorobenzene has great potential in the field of chemical industry. Future development is expected to emerge in the creation of medicine. Due to its unique structure, it may provide key intermediates for the synthesis of new drugs, help the progress of medicine, and cure more diseases.
Furthermore, in the field of materials science, there is also room for expansion. Or it can be specially treated to integrate high-tech materials to increase the properties of materials, such as improving conductivity and stability, to meet the needs of multiple fields such as electronics and aviation.
And with the advancement of science and technology, the synthesis process material will be optimized, the cost will be reduced, and the yield will be increased, making it more widely used. It will be able to bloom in the unfinished path, contributing to the prosperity of many industries.

Frequently Asked Questions

What is the chemistry of 4-Bromofluorobenzene?

4-Bromofluorobenzene is also an organic compound. It is active and has its effect in many chemical reactions.
As for the nucleophilic substitution reaction, the electron cloud density of the benzene ring decreases due to the strong electron-absorbing property of the fluorine atom, while the bromine atom can be used as the leaving group. Therefore, the nucleophilic reagent is easy to attack the benzene ring and replace the bromine atom to form a new organic compound.
In the electrophilic substitution reaction, although both fluorine and bromine are blunt groups, the localization effect of fluorine is strong, so that the electrophilic reagent attacks the neighbor and para-site of fluorine more. Due to the conjugation effect of fluorine and benzene ring, the density of the adjacent and para
4-bromofluorobenzene is also involved in metal-organic reactions. For example, it can react with magnesium to form Grignard reagents. This reagent has a wide range of uses and can react with a variety of carbonyl compounds to increase carbon chains and produce complex organic molecules.
Its physical properties are also unique. It is a liquid at room temperature and has a specific melting and boiling point. Due to the halogen atom, the density is higher than that of water. And due to molecular polarity, it has good solubility in organic solvents.
This compound is crucial in the field of organic synthesis. It can be used as an intermediate in the synthesis of medicines, pesticides, materials, etc. With its chemical reaction properties, it can construct organic molecules with diverse structures and promote the development of organic synthesis chemistry.

What are the main uses of 4-Bromofluorobenzene?

4-Bromofluorobenzene is a crucial raw material in the field of organic synthesis and has a wide range of applications in many industries.
In the field of pharmaceutical synthesis, it can act as a key intermediate. Through specific chemical reactions, 4-bromofluorobenzene can introduce specific functional groups to construct molecular structures with specific pharmacological activities. For example, when developing new antibacterial drugs, its unique structural characteristics can be used to synthesize compounds with precise antibacterial targets through multi-step reactions, opening up new paths for pharmaceutical research and development.
In the field of materials science, 4-bromofluorobenzene also plays an important role. In the preparation of high-performance polymer materials, it can participate in polymerization reactions as a comonomer. With its bromine and fluorine atoms, polymer materials are endowed with special properties such as excellent thermal stability, chemical stability and electrical properties, making such materials have broad application prospects in high-end fields such as electronic devices and aerospace.
Furthermore, in the synthesis of pesticides, 4-bromofluorobenzene is also indispensable. Through reasonable chemical modification, pesticides can be synthesized with high efficiency in the control of specific pests. Due to its structural particularity, it can enhance the selectivity and affinity of pesticides to target pests, enhance the efficacy while reducing the impact on non-target organisms, in line with the trend of green pesticide development.
In summary, 4-bromofluorobenzene, with its unique chemical structure, has shown important application value in many fields such as medicine, materials, and pesticides, and has made significant contributions to the development of various industries.

What are 4-Bromofluorobenzene synthesis methods?

4-Bromofluorobenzene is also an organic compound. There are many ways to synthesize it. Here are the following methods:
First, fluorobenzene is used as the starting material and obtained by bromination reaction. Place fluorobenzene in a suitable reaction vessel, add an appropriate amount of catalyst, such as iron powder or iron tribromide, and slowly add bromine dropwise. This reaction needs to start at low temperature and gradually rise to room temperature to ensure a smooth reaction. Bromine and fluorobenzene are electrophilically replaced, and the para-hydrogen of fluorobenzene is replaced by a bromine atom to obtain 4-bromofluorobenzene. The reaction mechanism is: bromine is polarized under the action of the catalyst to generate active bromine cations, attack the benzene ring of fluorobenzene, and form products through intermediates. The raw materials of this method are easy to obtain and the operation is relatively simple. However, the by-products in the product or containing ortho-substitution need to be carefully separated.
Second, 4-bromoaniline is used as the raw material and prepared by Sandmeier reaction. First, 4-bromoaniline is made into a diazonium salt, and 4-bromoaniline is obtained by treating 4-bromoaniline with sodium nitrite and hydrochloric acid at low temperature. Subsequently, the diazonium salt is reacted with fluoroboric acid to obtain 4-bromobenzene diazofluoroborate. After decomposition by heating, the diazonium group is replaced by a fluorine atom, and the final product is 4-bromofluorobenzene. In this process, the preparation of diazonium salt needs to be strictly controlled at temperature The Sandmaier reaction has good selectivity and can effectively obtain the target product. However, the steps are slightly more complicated, and the raw material needs to be synthesized in multiple steps.
Third, using 1,4-dibromobenzene as the raw material, it is synthesized by halogen exchange reaction. In a suitable solvent, add 1,4-dibromobenzene and fluorinating agents, such as potassium fluoride. A phase transfer catalyst is often added to promote the reaction. At high temperature, bromine atoms are exchanged with fluoride ions to obtain 4-bromofluorobenzene. This reaction takes advantage of the difference in halogen activity. The choice of fluorinating agent and the control of reaction conditions are extremely important. Its advantage is that the raw material is simple and can be industrially produced. However, the problems of corrosiveness and reaction efficiency of fluorinating agents need to be solved.

4-Bromofluorobenzene What are the precautions during storage and transportation?

4-Bromofluorobenzene is an organic compound. When storing and transporting, many matters must be paid attention to.
First words storage. Because of its certain chemical activity, it should be stored in a cool and ventilated warehouse. This is due to high temperature or poor ventilation, or its chemical reaction, causing danger. The temperature and humidity of the warehouse must also be properly controlled. The temperature should be maintained within a specific range to prevent its volatilization from being intensified due to excessive temperature, or due to excessive humidity and deliquescence and other adverse conditions. In addition, it should be stored separately from oxidants, acids, bases, etc., because it is easy to react with such substances, causing serious accidents such as fire and explosion. The storage place must also be kept away from fire and heat sources, and all fire sources must be eliminated, so as not to burn in case of open fire and cause unpredictable disasters.
Second talk about transportation. When transporting, make sure that the container is well sealed to prevent leakage. The transportation vehicles used should have corresponding safety facilities, such as fire protection and explosion-proof devices, to ensure safety. During transportation, drivers must be careful to avoid severe bumps and collisions to prevent the container from being damaged and causing leakage of 4-bromofluorobenzene. If the transportation route passes through a densely populated area, it must be carefully planned and avoided as much as possible. In case of leakage, it may cause great harm to people's lives and the environment. Transportation personnel should also be familiar with the characteristics of 4-bromofluorobenzene and emergency treatment methods. If something happens, they can respond quickly to reduce the harm. In short, the storage and transportation of 4-bromofluorobenzene is related to safety and must be carried out in accordance with regulations, and there must be no slack.

4-Bromofluorobenzene impact on the environment and human health

4-Bromofluorobenzene is also an organic compound. It has a considerable impact on the environment and human health.
As far as the environment is concerned, if this substance is released in nature, it is difficult to be naturally degraded due to its chemical stability, and it is easy to accumulate in the environment. If it enters the water body, it may cause water pollution and endanger the survival of aquatic organisms. After ingestion by aquatic organisms, it may damage their physiological functions, causing reproduction, growth impairment, and even death. And through the transmission and enrichment of the food chain, it will affect the gradual transition to higher trophic organisms and disrupt the balance of the ecosystem. In the soil, it will change the chemical properties of the soil, affect the absorption of nutrients by plants, and then inhibit crop growth and damage the soil ecological environment.
As for human health, 4-bromofluorobenzene has certain toxicity. After entering the body through breathing, skin contact or ingestion, it may irritate the respiratory tract and skin. If inhaled, it can cause cough, asthma, breathing difficulties and other symptoms; contact with the skin, or cause skin redness, itching, pain. Long-term exposure to this environment can also damage the nervous system and endocrine system of the human body. Nervous system involvement, or headache, dizziness, fatigue, memory loss, etc.; endocrine system damage, hormone secretion imbalance, affect the normal physiological function of the human body, severe cases or increase the risk of cancer. Therefore, the production, use and disposal of 4-bromofluorobenzene should be carried out with caution and strict environmental management and safety protection measures should be taken to reduce its harm to the environment and human health.