1 Bromo 2 Methylpropane Anti Zaytsev Rule
The Anti-Zaitsev Rule for 1-Bromo-2-Methylpropane
At some point, there was a chemical called 1-bromo-2-methylpropane. When it reacted, it took an unusual path and went against the Zaitsev Rule.
Common reaction rules, everyone thought that the product should follow Zaitsev's rules, that is, the resulting olefin is mostly the one with more alkyl substituents on the double-bonded carbon. However, 1-bromo-2-methylpropane is the opposite.
When placed under specific reaction conditions, such as under appropriate reagents and environments, it undergoes elimination reactions. It should have followed the convention to form a specific olefin. But it generates an olefin with fewer alkyl substituents on the double-bonded carbon. Everyone was surprised.
The reason is actually caused by the interaction of many factors in the reaction system. Or because of the characteristics of the reagent, it has a special promotion effect on the reaction in a specific direction; or because of the transition state formed during the reaction process, its stability is biased towards the formation of products of the anti-Zaitsev rule.
This 1-bromo-2-methylpropane anti-Zaitsev rule made everyone think and explore the chemical reaction law again.
